Summary | Mutation origin | Mutation description | Recombinase activity | Find Mice (IMSR) | References

Symbol:	Pnoctm1.1(cre)Jcbr
Name:	prepronociceptin; targeted mutation 1.1, Jens C Bruning
MGI ID:	MGI:6448945
Synonyms:	PNOC-Cre
Gene:	Pnoc  Location: Chr14:65638122-65662921 bp, - strand  Genetic Position: Chr14, 34.33 cM, cytoband D1
Alliance:	Pnoctm1.1(cre)Jcbr page

Germline Transmission:	Earliest citation of germline transmission: J:291152
Parent Cell Line:	Bruce 4 (ES Cell)
Strain of Origin:	B6.Cg-Thy1a

Allele Type:    Targeted (Null/knockout, Recombinase) Mutations:    Insertion, Intragenic deletion   Pnoctm1.1(cre)Jcbr expression driven by 1 gene Knock-in expression driven by: Organism Driver Gene Note mouse Pnoc (MGI:105308)   Mutation details: A targeting vector was designed that replaces exon 2, containing the ATG translation start-site of Pnoc, with Cre. Flp-mediated recombination removed the neo cassette. The allele is a null. (J:291152)

Activity:	Tissue activity of this recombinase allele
Driver:	Pnoc (mouse) Summary of all recombinase alleles driven by Pnoc. Alliance mouse Pnoc gene page

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Pnoc Mutation:	12 strains or lines available

Original:	J:291152 Jais A, et al., PNOC(ARC) Neurons Promote Hyperphagia and Obesity upon High-Fat-Diet Feeding. Neuron. 2020 Jun 17;106(6):1009-1025.e10
All:	1 reference(s)