Summary | Mutation origin | Mutation description | Find Mice (IMSR) | References

Symbol:	Hlcstm1.1Jze
Name:	holocarboxylase synthetase (biotin- [propriony-Coenzyme A-carboxylase (ATP-hydrolysing)] ligase); targeted mutation 1.1, Janos Zempleni
MGI ID:	MGI:6446223
Synonyms:	HLCS CKO
Gene:	Hlcs  Location: Chr16:93929741-94114430 bp, - strand  Genetic Position: Chr16, 55.12 cM, cytoband C4
Alliance:	Hlcstm1.1Jze page

Germline Transmission:	Earliest citation of germline transmission: J:322810
Parent Cell Line:	E14 (ES Cell)
Strain of Origin:	129P2/OlaHsd

Allele Type:    Targeted (Conditional ready) Mutation:    Insertion   Mutation details: The targeting vector is designed to insert a loxP site upstream of exon 8 and a second loxP site, followed by an FRT-flanked neomycin resistance (neo) cassette, downstream of exon 8. Flp-mediated recombination removed the FRT-flanked neo cassette. (J:322810)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Hlcs Mutation:	43 strains or lines available

Original:	J:322810 Sadri M, et al., Holocarboxylase synthetase knockout is embryonic lethal in mice. PLoS One. 2022;17(4):e0265539
All:	1 reference(s)