About   Help   FAQ
Gene Expression Data
Assay Details
Assay
Reference: J:242898 Lilly AJ, et al., SOX7 expression is critically required in FLK1-expressing cells for vasculogenesis and angiogenesis during mouse embryonic development. Mech Dev. 2017 Aug;146:31-41
Assay type: Immunohistochemistry
MGI Accession ID: MGI:6443691
Gene symbol: Pecam1
Gene name: platelet/endothelial cell adhesion molecule 1
Antibody: MEC 13.3
Detection system: Alexa Fluor 555
Results
Specimen 1E: embryonic day 10.5; Sox7tm1e(EUCOMM)Hmgu/Sox7+ (more )
Note: Triple labeled: green - Pecam1; red - Kit (assay MGI:6443689); blue - DAPI.
Structure Level Pattern Image Note
TS17: dorsal aorta Present Regionally restricted 1E (right) Expression in hematopoietic clusters.
Specimen 2B Sox7+/-: embryonic day 7.5; Sox7tm1e(EUCOMM)Hmgu/Sox7+ (more )
Structure Level Pattern Image Note
TS11: yolk sac endoderm Present Regionally restricted 2B Sox7+/- Expression in primordial endothelial precursor cells.
Specimen 2B Sox7-/-: embryonic day 7.5; Sox7tm1e(EUCOMM)Hmgu/Sox7tm1e(EUCOMM)Hmgu (more )
Structure Level Pattern Image Note
TS11: yolk sac endoderm Present Regionally restricted 2B Sox7-/- Expression in primordial endothelial precursor cells not affected overall.
Specimen 3A Sox7+/-: embryonic day 8.5; Sox7tm1e(EUCOMM)Hmgu/Sox7+ (more )
Note: 5-6 somite pairs
Structure Level Pattern Image Note
TS13: vascular element Present 3A Sox7+/-
TS13: yolk sac blood vessel Present 3A Sox7+/-
Specimen 3A Sox7-/-: embryonic day 8.5; Sox7tm1e(EUCOMM)Hmgu/Sox7tm1e(EUCOMM)Hmgu (more )
Note: 5-6 somite pairs
Structure Level Pattern Image Note
TS13: vascular element Present Regionally restricted 3A Sox7-/- Notable defects in developing vascular networks.
TS13: yolk sac blood vessel Present Regionally restricted 3A Sox7-/- Notable defects in developing vascular networks.
Specimen 3B Sox7+/-: embryonic day 8.5; Sox7tm1e(EUCOMM)Hmgu/Sox7+ (more )
Structure Level Pattern Image Note
TS13: dorsal aorta Present 3B Sox7+/-
Specimen 3B Sox7-/-: embryonic day 8.5; Sox7tm1e(EUCOMM)Hmgu/Sox7tm1e(EUCOMM)Hmgu (more )
Structure Level Pattern Image Note
TS13: dorsal aorta Present 3B Sox7-/- Anterior region of paired dorsal aorta was relatively unaffected.
Specimen 3C Sox7+/-: embryonic day 8.5; Sox7tm1e(EUCOMM)Hmgu/Sox7+ (more )
Structure Level Pattern Image Note
TS13: dorsal aorta Present 3C Sox7+/-
Specimen 3C Sox7-/-: embryonic day 8.5; Sox7tm1e(EUCOMM)Hmgu/Sox7tm1e(EUCOMM)Hmgu (more )
Structure Level Pattern Image Note
TS13: vascular system Present Regionally restricted 3C Sox7-/- Posterior region displayed areas of highly unorganised enothelial cords rather than distinct paired dorsal aorta.
Specimen 3D Sox7+/-: embryonic day 8.5; Sox7tm1e(EUCOMM)Hmgu/Sox7+ (more )
Note: 3-5 somite pairs
Structure Level Pattern Image Note
TS13: vascular system Present 3D Sox7+/-
Specimen 3D Sox7+/- (i): embryonic day 8.5; Sox7tm1e(EUCOMM)Hmgu/Sox7+ (more )
Note: 3-5 somite pairs
Structure Level Pattern Image Note
TS13: dorsal aorta Present 3D Sox7+/- (i)
Specimen 3D Sox7+/- (ii): embryonic day 8.5; Sox7tm1e(EUCOMM)Hmgu/Sox7+ (more )
Note: 3-5 somite pairs
Structure Level Pattern Image Note
TS13: dorsal aorta Present 3D Sox7+/- (ii)
Specimen 3D Sox7-/-: embryonic day 8.5; Sox7tm1e(EUCOMM)Hmgu/Sox7tm1e(EUCOMM)Hmgu (more )
Note: 3-5 somite pairs
Structure Level Pattern Image Note
TS13: vascular system Present 3D Sox7-/-
Specimen 3D Sox7-/- (i): embryonic day 8.5; Sox7tm1e(EUCOMM)Hmgu/Sox7tm1e(EUCOMM)Hmgu (more )
Note: 3-5 somite pairs
Structure Level Pattern Image Note
TS13: dorsal aorta Present Regionally restricted 3D Sox7-/- (i) Posterior regions of dorsal aorta were not lumenized.
Specimen 3D Sox7-/- (ii): embryonic day 8.5; Sox7tm1e(EUCOMM)Hmgu/Sox7tm1e(EUCOMM)Hmgu (more )
Note: 3-5 somite pairs
Structure Level Pattern Image Note
TS13: dorsal aorta Present Regionally restricted 3D Sox7-/- (ii) Posterior regions of dorsal aorta were not lumenized.
Specimen 3E Sox7+/-: embryonic day 8.5; Sox7tm1e(EUCOMM)Hmgu/Sox7+ (more )
Structure Level Pattern Image Note
TS13: yolk sac blood vessel Present 3E Sox7+/-
Specimen 3E Sox7-/-: embryonic day 8.5; Sox7tm1e(EUCOMM)Hmgu/Sox7tm1e(EUCOMM)Hmgu (more )
Structure Level Pattern Image Note
TS13: yolk sac blood vessel Present Regionally restricted 3E Sox7-/- Primitive vascular plexus within yolk sac appeared disorganized compared to that of controls.
Specimen 4A Sox7+/- (upper): embryonic day 10.5; Sox7tm1e(EUCOMM)Hmgu/Sox7+ (more )
Structure Level Pattern Image Note
TS17: vascular system Present 4A Sox7+/- (upper)
Specimen 4A Sox7+/- (lower): embryonic day 10.5; Sox7tm1e(EUCOMM)Hmgu/Sox7+ (more )
Structure Level Pattern Image Note
TS17: vascular system Present 4A Sox7+/- (lower)
Specimen 4A Sox7-/- (upper): embryonic day 10.5; Sox7tm1e(EUCOMM)Hmgu/Sox7tm1e(EUCOMM)Hmgu (more )
Structure Level Pattern Image Note
TS17: vascular system Present Regionally restricted 4A Sox7-/- (upper) Extremely severe vascular defects in embryo proper.
Specimen 4A Sox7-/- (lower): embryonic day 10.5; Sox7tm1e(EUCOMM)Hmgu/Sox7tm1e(EUCOMM)Hmgu (more )
Structure Level Pattern Image Note
TS17: vascular system Present Regionally restricted 4A Sox7-/- (lower) Absence of definitive dorsal aorta in posterior region of embryo.
Specimen 4B Sox7+/- (upper): embryonic day 10.5; Sox7tm1e(EUCOMM)Hmgu/Sox7+ (more )
Structure Level Pattern Image Note
TS17: yolk sac blood vessel Present 4B Sox7+/- (upper)
Specimen 4B Sox7+/- (lower): embryonic day 10.5; Sox7tm1e(EUCOMM)Hmgu/Sox7+ (more )
Structure Level Pattern Image Note
TS17: yolk sac blood vessel Present 4B Sox7+/- (lower)
Specimen 4B Sox7-/- (upper): embryonic day 10.5; Sox7tm1e(EUCOMM)Hmgu/Sox7tm1e(EUCOMM)Hmgu (more )
Structure Level Pattern Image Note
TS17: yolk sac blood vessel Present Regionally restricted 4B Sox7-/- (upper) Extremely severe vascular defects in yolk sac.
Specimen 4B Sox7-/- (lower): embryonic day 10.5; Sox7tm1e(EUCOMM)Hmgu/Sox7tm1e(EUCOMM)Hmgu (more )
Structure Level Pattern Image Note
TS17: yolk sac blood vessel Present Regionally restricted 4B Sox7-/- (lower) Yolk sac vasculatuer arresetd at primitive vascular plexus stage, with complete absence of vascular remodeling.
Specimen 6A Sox7fl/+: embryonic day 8.5; Sox7tm1a(EUCOMM)Hmgu/Sox7+ (more )
Structure Level Pattern Image Note
TS13: vascular system Present 6A Sox7 fl/+
Specimen 6A Flk1-Cre Sox7fl/fl: embryonic day 8.5; Kdrtm1(cre)Sato/Kdr+, Sox7tm1a(EUCOMM)Hmgu/Sox7tm1a(EUCOMM)Hmgu (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS13: vascular system Present Regionally restricted 6A Flk1-Cre Sox7 fl/fl Noticeable defects in developing vascular networks.
Specimen 6B Sox7fl/+: embryonic day 8.5; Sox7tm1a(EUCOMM)Hmgu/Sox7+ (more )
Structure Level Pattern Image Note
TS13: yolk sac blood vessel Present 6B Sox7 fl/+
Specimen 6B Flk1-Cre Sox7fl/fl: embryonic day 8.5; Kdrtm1(cre)Sato/Kdr+, Sox7tm1a(EUCOMM)Hmgu/Sox7tm1a(EUCOMM)Hmgu (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS13: yolk sac blood vessel Present Regionally restricted 6B Flk1-Cre Sox7 fl/fl Disorganized yolk sac vascular plexus.
Specimen 6C Sox7fl/+: embryonic day 8.5; Sox7tm1a(EUCOMM)Hmgu/Sox7+ (more )
Structure Level Pattern Image Note
TS13: dorsal aorta Present 6C Sox7 fl/+
Specimen 6C Flk1-Cre Sox7fl/fl: embryonic day 8.5; Kdrtm1(cre)Sato/Kdr+, Sox7tm1a(EUCOMM)Hmgu/Sox7tm1a(EUCOMM)Hmgu (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS13: dorsal aorta Present Regionally restricted 6C Flk1-Cre Sox7 fl/fl Highly unorganized endothelial cords in posterior region of dorsal oarta.
Specimen 6D Fox7fl/+: embryonic day 8.5; Sox7tm1a(EUCOMM)Hmgu/Sox7+ (more )
Structure Level Pattern Image Note
TS13: dorsal aorta Present 6D Sox7 fl/+
Specimen 6D Flk1-Cre Sox7fl/fl: embryonic day 8.5; Kdrtm1(cre)Sato/Kdr+, Sox7tm1a(EUCOMM)Hmgu/Sox7tm1a(EUCOMM)Hmgu (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS13: dorsal aorta Present Regionally restricted 6D Flk1-Cre Sox7 fl/fl Highly unorganized endothelial cords in posterior region of dorsal oarta.
Specimen 7A Sox7fl/+: embryonic day 10.5; Sox7tm1a(EUCOMM)Hmgu/Sox7+ (more )
Structure Level Pattern Image Note
TS17: vascular system Present 7A Sox7 fl/+
Specimen 7A Flk1-Cre Sox7fl/fl: embryonic day 10.5; Kdrtm1(cre)Sato/Kdr+, Sox7tm1a(EUCOMM)Hmgu/Sox7tm1a(EUCOMM)Hmgu (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS17: vascular system Present Regionally restricted 7A Flk1-Cre Sox7 fl/fl Highly unorganized nature of vascular networks indicative of consideral angiogenic defets.
Specimen 7B Sox7fl/+ (upper): embryonic day 10.5; Sox7tm1a(EUCOMM)Hmgu/Sox7+ (more )
Structure Level Pattern Image Note
TS17: trunk blood vessel Present 7B Sox7 fl/+ (upper)
Specimen 7B Sox7fl/+ (lower): embryonic day 10.5; Sox7tm1a(EUCOMM)Hmgu/Sox7+ (more )
Structure Level Pattern Image Note
TS17: vitelline artery Present 7B Sox7 fl/+ (lower)
Specimen 7B Flk1-Cre Sox7fl/fl (upper): embryonic day 10.5; Kdrtm1(cre)Sato/Kdr+, Sox7tm1a(EUCOMM)Hmgu/Sox7tm1a(EUCOMM)Hmgu (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS17: trunk blood vessel Present Regionally restricted 7B Flk1-Cre Sox7 fl/fl (upper) Marked defects in formation of major blood vessels in embryo.
Specimen 7B Flk1-Cre Sox7fl/fl (lower): embryonic day 10.5; Kdrtm1(cre)Sato/Kdr+, Sox7tm1a(EUCOMM)Hmgu/Sox7tm1a(EUCOMM)Hmgu (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS17: vitelline artery Absent 7B Flk1-Cre Sox7 fl/fl (lower) Lack of observable vitelline artery in embryo proper.
Specimen 7C Sox7fl/+: embryonic day 10.5; Sox7tm1a(EUCOMM)Hmgu/Sox7+ (more )
Structure Level Pattern Image Note
TS17: dorsal aorta Present 7C Sox7 fl/fl
Specimen 7C Flk1-Cre Sox7fl/fl: embryonic day 10.5; Kdrtm1(cre)Sato/Kdr+, Sox7tm1a(EUCOMM)Hmgu/Sox7tm1a(EUCOMM)Hmgu (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS17: dorsal aorta Present Regionally restricted 7C Flk1-Cre Sox7 fl/fl Posterior region of dorsal aorta resembling cord of endothelial cells.
Specimen 8A: embryonic day 9.5; Kdrtm1(cre)Sato/Kdr+, Sox7tm1a(EUCOMM)Hmgu/Sox7tm1a(EUCOMM)Hmgu (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS15: vascular system Present Regionally restricted 8A (left) , 8A (right) Mass of disorganized endothelial cells.
Specimen 8B: embryonic day 9.5; Kdrtm1(cre)Sato/Kdr+, Sox7tm1a(EUCOMM)Hmgu/Sox7tm1a(EUCOMM)Hmgu (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS15: blood vessel Present Regionally restricted 8B (left) , 8B (right) Clear evidence of lumenization defects in a major blood vessel.
Specimen 9A Control yolk sac venous: embryonic day 10.5; Sox7tm1a(EUCOMM)Hmgu/Sox7+ (more )
Structure Level Pattern Image Note
TS17: vitelline vein Present 9A Control yolk sac venous
TS17: yolk sac blood vessel Present 9A Control yolk sac venous
Specimen 9A Control yolk sac arterial: embryonic day 10.5; Sox7tm1a(EUCOMM)Hmgu/Sox7+ (more )
Structure Level Pattern Image Note
TS17: vitelline artery Present 9A Control yolk sac arterial
TS17: yolk sac blood vessel Present 9A Control yolk sac arterial
Specimen 9A Flk1-Cre Sox7fl/fl yolk sac: embryonic day 10.5; Kdrtm1(cre)Sato/Kdr+, Sox7tm1a(EUCOMM)Hmgu/Sox7tm1a(EUCOMM)Hmgu (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS17: yolk sac blood vessel Present Regionally restricted 9A Flk1-Cre Sox7 fl/fl yolk sac Yolk sac vasculature arrested at primitive vascular plexus stage, with complete absence of vascular remodeling.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
03/25/2025
MGI 6.24 		The Jackson Laboratory