Rbfox2em1Akal
Endonuclease-mediated Allele Detail
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| Symbol: |
Rbfox2em1Akal |
| Name: |
RNA binding protein, fox-1 homolog (C. elegans) 2; endonuclease-mediated mutation 1, Auinash Kalsotra |
| MGI ID: |
MGI:6442563 |
| Synonyms: |
Rbfox2delta43 |
| Gene: |
Rbfox2 Location: Chr15:76963190-77191204 bp, - strand Genetic Position: Chr15, 36.4 cM, cytoband E1
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| Alliance: |
Rbfox2em1Akal page
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| Allele Type: |
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Endonuclease-mediated (Modified isoform(s)) |
| Mutation: |
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Intragenic deletion
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Mutation details: CRISPR/Cas9 technology generated a 1.4 kb deletion that includes the 43 nucleotide muscle-specific exon. Western blot analysis confirmed the expression of the non-muscle isoform.
(J:286588)
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| Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
| Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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| Carrying any Rbfox2 Mutation: |
80 strains or lines available
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| Original: |
J:286588 Misra C, et al., Aberrant Expression of a Non-muscle RBFOX2 Isoform Triggers Cardiac Conduction Defects in Myotonic Dystrophy. Dev Cell. 2020 Mar 23;52(6):748-763.e6 |
| All: |
1 reference(s) |
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Analysis Tools
