Ret RNA in situ Gene Expression Assay

Gene Expression Data
Assay Details

Assay

Reference:	J:230339 Jiang Q, et al., Functional loss of semaphorin 3C and/or semaphorin 3D and their epistatic interaction with ret are critical to Hirschsprung disease liability. Am J Hum Genet. 2015 Apr 2;96(4):581-96
Assay type:	RNA in situ
MGI Accession ID:	MGI:6441812
Gene symbol:	Ret
Gene name:	ret proto-oncogene

Probe:	ret probe19
Probe preparation:	Antisense RNA

Results

Specimen 2A E11.5: embryonic day 11.5 (more

)

Structure	Level	Pattern	Image	Note
TS19: enteric nervous system	Present	Regionally restricted	2A upper Ret	Expressed in enteric neural crest-derived cells in the developing gut.
TS19: gut	Present	Regionally restricted	2A upper Ret	Expressed in enteric neural crest-derived cells in the developing gut.
TS19: migrating neural crest	Present	Regionally restricted	2A upper Ret	Expressed in enteric neural crest-derived cells in the developing gut.

Specimen 2A E15.5: embryonic day 15.5 (more

)

Structure	Level	Pattern	Image	Note
TS23: enteric nervous system	Present	Regionally restricted	2A middle Ret	Expressed in the myenteric plexus of the intestine, which is situated within the outer muscular layers of the gut.
TS23: intestine	Present	Regionally restricted	2A middle Ret	Expressed in the myenteric plexus of the intestine, which is situated within the outer muscular layers of the gut.

Specimen 2A P3: postnatal day 3 (more

)

Structure	Level	Pattern	Image	Note
TS27: intrinsic nerve plexus	Present	Regionally restricted	2A lower Ret	Expressed in the newly forming sub-mucosal plexus.
TS27: myenteric nerve plexus	Present		2A lower Ret

Specimen 6A/6B WT: embryonic day 15.5 (more

)

Structure	Level	Pattern	Image	Note
TS23: enteric nervous system	Present		6B Ret left , 6A
TS23: intestine	Present	Regionally restricted	6B Ret left , 6A	Expressed in the myenteric plexus, forming a nearly complete ring in the outer layers of the intestine.

Specimen 6B mut: embryonic day 15.5; Ret^tm1Cos/Ret^tm1Cos (more

)

Structure	Level	Pattern	Image	Note
TS23: enteric nervous system	Absent		6B Ret right	The enteric nervous system was absent in the mutant.

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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