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Gene Expression Data
Assay Details
Assay
Reference: J:77320 Wilson ME, et al., Expression pattern of IAPP and prohormone convertase 1/3 reveals a distinctive set of endocrine cells in the embryonic pancreas. Mech Dev. 2002 Jul;115(1-2):171-6
Assay type: Immunohistochemistry
MGI Accession ID: MGI:6441722
Gene symbol: Iapp
Gene name: islet amyloid polypeptide
Antibody: Amylin antibody
Detection system: Secondary antibody coupled to Alexa Fluor 488
Results
Specimen 3 e10.5 IAPP: embryonic day 10.5 (more )
Structure Level Pattern Image Note
TS17: pancreas primordium Present Regionally restricted 3_e10.5 IAPP Expression in pancreatic bud first appears at E10.5. Co-expression with proglucagon.
Specimen 3 e12.5 (upper) IAPP: embryonic day 12.5 (more )
Note: Double labeled: green - Iapp; red - Gcg (assay MGI:6441719).
Structure Level Pattern Image Note
TS20: pancreas Present Regionally restricted 3_e12.5 Glucagon/IAPP Co-expression with proglucagon continues throughout fetal development of pancreas. At E12.5, co-expression in majority of Gcg-expressing cells.
Specimen 3 e12.5 (lower) IAPP: embryonic day 12.5 (more )
Note: Double labeled: green - Iapp; red - Ins1 (assay MGI:6441724) and Ins2 (assay MGI:6441725).
Structure Level Pattern Image Note
TS20: pancreas Present Regionally restricted 3_e12.5 Insulin/IAPP Expression in all insulin-expressing cells.
Specimen 3 e15.5 IAPP: embryonic day 15.5 (more )
Note: Double labeled: green - Iapp; red - Gcg (assay MGI:6441719).
Structure Level Pattern Image Note
TS23: pancreas Present Regionally restricted 3_e15.5 IAPP/Glucagon Expression in about 60% of Gcg-expressing cells.
Specimen 3 e18.5 IAPP: embryonic day 18.5 (more )
Note: Double labeled: green - Iapp; red - Gcg (assay MGI:6441719).
Structure Level Pattern Image Note
TS26: pancreas Present Regionally restricted 3_e18.5 IAPP/Glucagon Proportion of Gcg-expressing cells expressing Iapp falls to approximately 20%.
Specimen adult pancreas not shown: postnatal adult (more )
Structure Level Pattern Image Note
TS28: pancreas Present Regionally restricted Expression in beta and delta cells, but rarely in alpha cells.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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04/30/2024
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