Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Tesminem1Osb
Name:	testis expressed metallothionein like; endonuclease-mediated mutation 1, Research Institute for Microbial Diseases, Osaka University
MGI ID:	MGI:6437394
Synonyms:	Mtl5em1Osb
Gene:	Tesmin  Location: Chr19:3438857-3457823 bp, + strand  Genetic Position: Chr19, 3.15 cM, cytoband B
Alliance:	Tesminem1Osb page

Strain of Origin:

(C57BL/6NJcl x DBA/2NJcl)F2

Allele Type:    Endonuclease-mediated (Null/knockout) Mutation:    Intragenic deletion   Mutation details: CRISPR/Cas9 technology generated a 316 bp deletion that includes the entire exon 3 resulting in a frameshift. Western blot analysis confirmed the absence of TESMIN-L protein and RT-PCR confirmed the absence of Tesmin-S transcript. (J:288964)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

2 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 5 strains available      Cell Lines: 0 lines available
Carrying any Tesmin Mutation:	25 strains or lines available

Original:	J:288964 Oji A, et al., Tesmin, Metallothionein-Like 5, is Required for Spermatogenesis in Mice. Biol Reprod. 2020 Apr 15;102(4):975-983
All:	2 reference(s)