About   Help   FAQ
Gene Expression Data
Assay Details
Assay
Reference: J:287370 Chen W, et al., Stxbp1/Munc18-1 haploinsufficiency impairs inhibition and mediates key neurological features of STXBP1 encephalopathy. Elife. 2020 Feb 19;9:e48705
Assay type: Western blot
MGI Accession ID: MGI:6437204
Gene symbol: Stxbp1
Gene name: syntaxin binding protein 1
Antibody: anti-Stxbp1
Detection system: Secondary antibody coupled to other - see notes
Assay notes: The antibody used in this assay recognizes the carboxyl terminus of the protein. It was detected using a secondary conjugated with IRDye 680LT, allowing for visualization and quantification, which is presented in part C of the figure.
Results
 Sample Information Bands Other Sample Information
Lane AgeStructure Size Not Specified Genetic BackgroundMutant Allele(s)Sex
+/+ E17.5 TS25: brain Present C57BL/6 Not Specified
+/- E17.5 TS25: brain Present (a) B6(Cg)-Stxbp1tm1d(EUCOMM)Hmgu Stxbp1tm1d(EUCOMM)Hmgu/Stxbp1+Not Specified
-/- E17.5 TS25: brain Absent B6(Cg)-Stxbp1tm1d(EUCOMM)Hmgu Stxbp1tm1d(EUCOMM)Hmgu/Stxbp1tm1d(EUCOMM)HmguNot Specified
Notes:
(a) Expression levels are reduced 50% in the hets.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
04/23/2024
MGI 6.23 		The Jackson Laboratory