Summary | Mutation origin | Mutation description | Find Mice (IMSR) | References

Symbol:	Ikzf3tm1.1Cjwu
Name:	IKAROS family zinc finger 3; targeted mutation 1.1, Catherine Wu
MGI ID:	MGI:6437069
Synonyms:	Ikzf3-L161R
Gene:	Ikzf3  Location: Chr11:98355728-98436857 bp, - strand  Genetic Position: Chr11, 61.75 cM
Alliance:	Ikzf3tm1.1Cjwu page

Germline Transmission:	Earliest citation of germline transmission: J:303191
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	Not Specified

Allele Type:    Targeted (Conditional ready, Humanized sequence) Mutations:    Insertion, Nucleotide substitutions   Mutation details: The targeting vector contains a loxP site inserted downstream of exon 4 and a second loxP, site followed by a STOP codon, downstream of exon 8 of the gene. An FRT-flanked neomycin resistance cassette and cDNA encoding exons 5, containing a leucine to arginine mutation (L161R), followed by exons 6-8, were inserted downstream of the second loxP site. Flp-mediated recombination removed the FRT-flanked neo cassette. The L161R mutation is analogous to the human IKZF3-L162R mutation associated with malignant transformation of B cells in chronic lymphocytic leukemia (CLL). (J:303191)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Ikzf3 Mutation:	30 strains or lines available

Original:	J:303191 Lazarian G, et al., A hotspot mutation in transcription factor IKZF3 drives B cell neoplasia via transcriptional dysregulation. Cancer Cell. 2021 Mar 8;39(3):380-393.e8
All:	1 reference(s)