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Del(3Gpr89-Prkab2)4Tac
Transgene Detail
Summary
Symbol: Del(3Gpr89-Prkab2)4Tac
Name: deletion, Chr 3, Taconic 4
MGI ID: MGI:6431412
Synonyms: Del1Tac, Del(3Gpr89-Prkab2)1Tac
Transgene: Del(3Gpr89-Prkab2)4Tac  Location: unknown  Genetic Position: Chr3, Syntenic
Alliance: Del(3Gpr89-Prkab2)4Tac page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:375517
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  C57BL/6NTac
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intergenic deletion, Intragenic deletion
  Del(3Gpr89-Prkab2)4Tac involves 20 genes/genome features (Pdzk1, Gpr89, Gja8 ...) View all
 
Mutation details: The first vector introduced a loxP site upstream of the Gpr89 gene. The second vector introduced a loxP site downstream of the Prkab2 gene. Homologous recombinant clones were isolated and the 0.8 megabase region on mouse chromosome 3 between the loxP sites was removed using in vitro Cre-mediated recombination. This deletion corresponds to human chromosome region 1q21.1. (J:147112, J:375517)
Expression
In Mice Carrying this Mutation: 1 RNA-Seq or microarray experiment(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
References
Original:  J:375517 Nielsen J, et al., A mouse model of the schizophrenia-associated 1q21.1 microdeletion syndrome exhibits altered mesolimbic dopamine transmission. Transl Psychiatry. 2017 Nov 30;7(11):1261
All:  3 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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Send questions and comments to User Support. 		last database update
01/06/2026
MGI 6.24 		The Jackson Laboratory