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Gene Expression Data
Assay Details
Assay
Reference: J:272566 Yang R, et al., CDK5RAP3, a UFL1 substrate adaptor, is crucial for liver development. Development. 2019 Jan 25;146(2):dev169235
Assay type: Immunohistochemistry
MGI Accession ID: MGI:6423305
Gene symbol: Hnf4a
Gene name: hepatic nuclear factor 4, alpha
Antibody: Anti-HNF-4-alpha [EPR16885] (ab181604)
Detection system: Secondary antibody coupled to horseradish peroxidase
Results
Specimen 3G: embryonic day 16.5 (more )
Structure Level Pattern Image Note
TS24: liver Present 3G
Specimen 3G': embryonic day 16.5; Cdk5rap3tm1b(EUCOMM)Hmgu/Cdk5rap3tm1b(EUCOMM)Hmgu (more )
Structure Level Pattern Image Note
TS24: liver Weak 3G' Expression was dramatically decreased in knockout livers.
Specimen 5G: postnatal month 1 (more )
Note: The genetic background of the conditional control specimen was not specified.
Structure Level Pattern Image Note
TS28: liver Present Regionally restricted 5G Expression was detected in hepatocytes.
Specimen 5G': postnatal month 1; Cdk5rap3tm1c(EUCOMM)Hmgu/Cdk5rap3tm1c(EUCOMM)Hmgu, Tg(Foxa3-cre)1Khk/0 (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS28: liver Weak Regionally restricted 5G' Decreased expression in the conditional knockout liver suggested that Cdk5rap3-deficient hepatocytes are less mature.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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03/25/2025
MGI 6.24 		The Jackson Laboratory