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Gene Expression Data
Assay Details
Assay
Reference: J:199301 Lavado A, et al., Tumor suppressor Nf2 limits expansion of the neural progenitor pool by inhibiting Yap/Taz transcriptional coactivators. Development. 2013 Aug;140(16):3323-34
Assay type: Immunohistochemistry
MGI Accession ID: MGI:6416317
Gene symbol: Nes
Gene name: nestin
Antibody: clone RC2
Results
Specimen 3A: embryonic day 14.5 (more )
Note: The genetic background of the conditional control specimen was not specified. Double labeled: green - Nes; red - Lmx1a (assay MGI:6416278).
Structure Level Pattern Image Note
TS22: telencephalon ventricular layer Weak Regionally restricted 3A , 3A' Weak expression was detected in the cortical hem.
Specimen 3B: embryonic day 16.5 (more )
Note: The genetic background of the conditional control specimen was not specified. Double labeled: green - Nes; red - Lmx1a (assay MGI:6416278).
Structure Level Pattern Image Note
TS24: telencephalon ventricular layer Trace Regionally restricted 3B' , 3B Expression was further diminished at E16.5 in the cortical hem.
TS24: dentate gyrus primordium Present 3B' , 3B
Specimen 3C: embryonic day 18.5 (more )
Note: The genetic background of the conditional control specimen was not specified. Double labeled: green - Nes; red - Lmx1a (assay MGI:6416278).
Structure Level Pattern Image Note
TS26: telencephalon ventricular layer Ambiguous 3C , 3C'
Specimen 3D: embryonic day 14.5; Nf2tm2Gth/Nf2tm2Gth, Emx1tm1(cre)Krj/Emx1+ (more )
Note: Conditional mutant. Double labeled: green - Nes; red - Lmx1a (assay MGI:6416278).
Structure Level Pattern Image Note
TS22: telencephalon ventricular layer Present Regionally restricted 3D , 3D' Expression in the cortical hem of the conditional mutant was much higher compared to the control at E14.5.
Specimen 3E: embryonic day 16.5; Nf2tm2Gth/Nf2tm2Gth, Emx1tm1(cre)Krj/Emx1+ (more )
Note: Conditional mutant. Double labeled: green - Nes; red - Lmx1a (assay MGI:6416278).
Structure Level Pattern Image Note
TS24: telencephalon ventricular layer Present Regionally restricted 3E' , 3E Expression in the cortical hem of the conditional mutant continued to be higher compared to the control at E16.5.
TS24: dentate gyrus primordium Present 3E , 3E'
Specimen 3F: embryonic day 18.5; Nf2tm2Gth/Nf2tm2Gth, Emx1tm1(cre)Krj/Emx1+ (more )
Note: Conditional mutant. Double labeled: green - Nes; red - Lmx1a (assay MGI:6416278).
Structure Level Pattern Image Note
TS26: telencephalon ventricular layer Weak Regionally restricted 3F' , 3F Expression in the cortical hem of the conditional mutant only became diminished by E18.5.
Specimen 4U: embryonic day 17.5 (more )
Note: The genetic background of the conditional control specimen was not specified.
Structure Level Pattern Image Note
TS25: hippocampus Weak Regionally restricted 4U Expression was detected at low levels in neuroprogenitor cells.
Specimen 4V: embryonic day 17.5; Nf2tm2Gth/Nf2tm2Gth, Emx1tm1(cre)Krj/Emx1+ (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS25: hippocampus Strong Regionally restricted 4V Expression was markedly stronger in the mutant hippocampus compared to control.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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03/25/2025
MGI 6.24 		The Jackson Laboratory