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Gene Expression Data
Assay Details
Assay
Reference: J:199301 Lavado A, et al., Tumor suppressor Nf2 limits expansion of the neural progenitor pool by inhibiting Yap/Taz transcriptional coactivators. Development. 2013 Aug;140(16):3323-34
Assay type: Immunohistochemistry
MGI Accession ID: MGI:6416258
Gene symbol: Tjp1
Gene name: tight junction protein 1
Antibody: Anti-ZO-1 (clone ZO1-1A12; 33-9100)
Detection system: Alexa Fluor 488
Results
Specimen 1E: embryonic day 12.5 (more )
Note: The genetic background of the conditional control specimen was not specified. Triple labeled: green - Tjp1; red - Nf2 (assay MGI:6416155); magenta - Ctnnb1 (assay MGI:6416257).
Structure Level Pattern Image Note
TS20: neocortex Present 1E Merge , 1E ZO-1 Expression was detected in apical junctions in neural progenitor cells.
Specimen 1F: embryonic day 12.5; Nf2tm2Gth/Nf2tm2Gth, Emx1tm1(cre)Krj/Emx1+ (more )
Note: Conditional mutant. Triple labeled: green - Tjp1; red - Nf2 (assay MGI:6416155); magenta - Ctnnb1 (assay MGI:6416257).
Structure Level Pattern Image Note
TS20: neocortex Present 1F ZO-1 , 1F Merge Loss of Nf2 did not affect the localization of Tjp1.
Specimen S1C: embryonic day 15.5 (more )
Note: The genetic background of the conditional control specimen was not specified.
Structure Level Pattern Image Note
TS23: telencephalon Present Regionally restricted S1C Expression was detected in apical junctions in dorsal telencephalon.
Specimen S1D: embryonic day 15.5; Nf2tm2Gth/Nf2tm2Gth, Emx1tm1(cre)Krj/Emx1+ (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS23: telencephalon Present Regionally restricted S1D Loss of Nf2 did not affect the localization of Tjp1 in the dorsal telencephalon.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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03/25/2025
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