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Gene Expression Data
Assay Details
Assay
Reference: J:242313 Forge A, et al., Disruption of SorCS2 reveals differences in the regulation of stereociliary bundle formation between hair cell types in the inner ear. PLoS Genet. 2017 Mar;13(3):e1006692
Assay type: Immunohistochemistry
MGI Accession ID: MGI:6414886
Gene symbol: Gnai3
Gene name: G protein subunit alpha i3
Antibody: Anti-G-alpha-i3 (G4040)
Detection system: Secondary antibody coupled to Alexa Fluor
Results
Specimen 11C normal: postnatal day 1 (more )
Note: Littermate control; mouse might carry the Cre transgene. Double labeled: green - Gnai3; red - actin.
Structure Level Pattern Image Note
TS27: organ of Corti Present Regionally restricted 11C , 11C' Expression localised to the surface of the outer and inner hair cells, specifically at the lateral pole.
Specimen 11D affected: postnatal day 1; Tg(Tek-cre)1Ywa/Tg(Tek-cre)1Ywa (more )
Note: Double labeled: green - Gnai3; red - actin
Structure Level Pattern Image Note
TS27: organ of Corti Absent 11D' , 11D No expression is seen in hair cells.
Specimen 12C normal: postnatal day 1 (more )
Note: Littermate control; mouse might carry the Cre transgene. Double labeled: green - Gnai3; red - actin.
Structure Level Pattern Image Note
TS27: macula of utricle Present Regionally restricted 12C , 12C' Expression is seen in the hair cells, in a lateral compartment on the apical surface.
Specimen 12D affected: postnatal day 1; Tg(Tek-cre)1Ywa/Tg(Tek-cre)1Ywa (more )
Note: Double labeled: green - Gnai3; red - actin
Structure Level Pattern Image Note
TS27: macula of utricle Absent 12D' , 12D No expression is seen in hair cells.
Specimen 13C normal: postnatal day 1 (more )
Note: Littermate control; mouse might carry the Cre transgene. Double labeled: green - Gnai3; red - actin.
Structure Level Pattern Image Note
TS27: crista ampullaris Present 13C' , 13C Expression is seen on the surface of the hair cells.
Specimen 13D affected: postnatal day 1; Tg(Tek-cre)1Ywa/Tg(Tek-cre)1Ywa (more )
Note: Double labeled: green - Gnai3; red - actin
Structure Level Pattern Image Note
TS27: crista ampullaris Absent 13D , 13D' No expression is seen in hair cells.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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04/23/2024
MGI 6.23 		The Jackson Laboratory