Summary | Mutation origin | Mutation description | Recombinase activity | Find Mice (IMSR) | References

Symbol:	Ccr2em1(icre/ERT2)Peng
Name:	C-C motif chemokine receptor 2; endonuclease-mediated mutation 1, Bo Peng
MGI ID:	MGI:6414749
Synonyms:	CCR2-CreER-GFP
Gene:	Ccr2  Location: Chr9:123901987-123913594 bp, + strand  Genetic Position: Chr9, 75.05 cM, cytoband F
Alliance:	Ccr2em1(icre/ERT2)Peng page

Strain of Origin:

C57BL/6N

Allele Type:    Endonuclease-mediated (Inducible, Recombinase, Reporter) Inducer:    tamoxifen Mutation:    Insertion   Ccr2em1(icre/ERT2)Peng expression driven by 1 gene Knock-in expression driven by: Organism Driver Gene Note mouse Ccr2 (MGI:106185)   Mutation details: Plasmids encoding a guide RNA was designed to insert a improved icre-ER fusion gene (an iCre recombinase fused to a human estrogen receptor ligand binding domain) between exon 3 and the 3' UTR of the chemokine (C-C motif) receptor 2 (Ccr2) gene. An enhanced green fluorescent protein (EGFP) sequence was inserted downstream of the icre-ER, and viral P2A oligopeptides, from porcine teschovirus-1, flank the icre-ER fusion gene to mediate ribosomal skipping. (J:292441)

Activity:	Tissue activity of this recombinase allele
Driver:	Ccr2 (mouse) Summary of all recombinase alleles driven by Ccr2. Alliance mouse Ccr2 gene page

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Ccr2 Mutation:	40 strains or lines available

Original:	J:292441 Xu Z, et al., Efficient Strategies for Microglia Replacement in the Central Nervous System. Cell Rep. 2020 Aug 11;32(6):108041
All:	2 reference(s)