Fgf8 RNA in situ Gene Expression Assay

Gene Expression Data
Assay Details

Assay

Reference:	J:146434 Maatouk DM, et al., In the limb AER Bmp2 and Bmp4 are required for dorsal-ventral patterning and interdigital cell death but not limb outgrowth. Dev Biol. 2009 Mar 15;327(2):516-23
Assay type:	RNA in situ
MGI Accession ID:	MGI:6403986
Gene symbol:	Fgf8
Gene name:	fibroblast growth factor 8

Probe:

Fgf8 probe101

Results

3B left ©

3B right ©

Specimen 3B: embryonic day 11.5; Bmp2^tm1Cjt/Bmp2^tm1Cjt, Bmp4^tm1Jfm/Bmp4^tm1Jfm (more

)

Structure	Level	Pattern	Image	Note
TS19: footplate apical ectodermal ridge	Present		3B left , 3B right

3D left ©

3D right ©

Specimen 3D: embryonic day 11.5; Bmp2^tm1Cjt/Bmp2^tm1Cjt, Bmp4^tm1Jfm/Bmp4^tm1Jfm, Tg(Msx2-cre)5Rem/0 (more

)
Note: Conditional mutant.

Structure	Level	Pattern	Image	Note
TS19: footplate apical ectodermal ridge	Present	Regionally restricted	3D left , 3D right	Expression expanded in both dorsal-ventral and anterior-posterior directions.

3E left ©

3E right ©

Specimen 3E: embryonic day 11.5; Bmp2^tm1Cjt/Bmp2⁺, Bmp4^tm1Jfm/Bmp4^tm1Jfm (more

)

Structure	Level	Pattern	Image	Note
TS19: footplate apical ectodermal ridge	Present		3E left , 3E right

3F left ©

3F right ©

Specimen 3F: embryonic day 11.5; Bmp2^tm1Cjt/Bmp2^tm1Cjt, Bmp4^tm1Jfm/Bmp4⁺ (more

)

Structure	Level	Pattern	Image	Note
TS19: footplate apical ectodermal ridge	Present		3F left , 3F right

3G left ©

3G right ©

Specimen 3G: embryonic day 11.5; Bmp2^tm1Cjt/Bmp2⁺, Bmp4^tm1Jfm/Bmp4^tm1Jfm, Tg(Msx2-cre)5Rem/0 (more

)
Note: Conditional mutant.

Structure	Level	Pattern	Image	Note
TS19: footplate apical ectodermal ridge	Present		3G right , 3G left	No ectopic expression in limbs with at least a single wild type allele of Bmp2 or Bmp4.

3H left ©

3H right ©

Specimen 3H: embryonic day 11.5; Bmp2^tm1Cjt/Bmp2^tm1Cjt, Bmp4^tm1Jfm/Bmp4⁺, Tg(Msx2-cre)5Rem/0 (more

)
Note: Conditional mutant.

Structure	Level	Pattern	Image	Note
TS19: footplate apical ectodermal ridge	Present		3H right , 3H left	No ectopic expression in limbs with at least a single wild type allele of Bmp2 or Bmp4.

S1A left ©

S1A right ©

Specimen S1A: embryonic day 12.5; Bmp2^tm1Cjt/Bmp2^tm1Cjt, Bmp4^tm1Jfm/Bmp4^tm1Jfm (more

)

Structure	Level	Pattern	Image	Note
TS20: foot epithelium	Present	Regionally restricted	S1A right , S1A left

S1B left ©

S1B right ©

Specimen S1B: embryonic day 14.5; Bmp2^tm1Cjt/Bmp2^tm1Cjt, Bmp4^tm1Jfm/Bmp4^tm1Jfm (more

)

Structure	Level	Pattern	Image	Note
TS22: foot skin	Ambiguous		S1B right , S1B left

S1C left ©

S1C right ©

Specimen S1C: embryonic day 12.5; Bmp2^tm1Cjt/Bmp2^tm1Cjt, Bmp4^tm1Jfm/Bmp4^tm1Jfm, Tg(Msx2-cre)5Rem/0 (more

)
Note: Conditional mutant.

Structure	Level	Pattern	Image	Note
TS20: foot epithelium	Present	Regionally restricted	S1C left , S1C right	Expression expanded in both dorsal-ventral and anterior-posterior directions.

S1D left ©

S1D right ©

Specimen S1D: embryonic day 14.5; Bmp2^tm1Cjt/Bmp2^tm1Cjt, Bmp4^tm1Jfm/Bmp4^tm1Jfm, Tg(Msx2-cre)5Rem/0 (more

)
Note: Conditional mutant.

Structure	Level	Pattern	Image	Note
TS22: hindlimb interdigital region	Ambiguous		S1D left , S1D right	Authors report ectopic expression.

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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