Summary | Mutation origin | Mutation description | Find Mice (IMSR) | References

Symbol:	Myf5tm3Tajb
Name:	myogenic factor 5; targeted mutation 3, Shahragim Tajbakhsh
MGI ID:	MGI:6403683
Synonyms:	Myf5NH(loxP)
Gene:	Myf5  Location: Chr10:107318769-107321995 bp, - strand  Genetic Position: Chr10, 55.95 cM
Alliance:	Myf5tm3Tajb page

Germline Transmission:	Earliest citation of germline transmission: J:92799
Parent Cell Line:	CK35 (ES Cell)
Strain of Origin:	129S2/SvPas

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: A targeting vector replaced the amino-terminal domain with a floxed neomycin and hygromycin resistance cassette upstream of the basic helix-loop-helix domain. The endogenous ATG was mutated to GTG, leaving the first ATG codons suitable for translation located in the chromatin remodeling and basic domains, at residues 69 and 82, respectively. This alleles was used to generate Myf5tm2Tajb. (J:92799)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Myf5 Mutation:	17 strains or lines available

Original:	J:92799 Kassar-Duchossoy L, et al., Mrf4 determines skeletal muscle identity in Myf5:Myod double-mutant mice. Nature. 2004 Sep 23;431(7007):466-71
All:	1 reference(s)