Summary | Mutation origin | Mutation description | Find Mice (IMSR) | References

Symbol:	Sod1tm1.1(SOD1)Emcf
Name:	superoxide dismutase 1, soluble; targeted mutation 1, Elizabeth MC Fisher
MGI ID:	MGI:6403195
Synonyms:	SOD1-3-A10-Flp excised
Gene:	Sod1  Location: Chr16:90017650-90023221 bp, + strand  Genetic Position: Chr16, 51.56 cM, cytoband B5-C3
Alliance:	Sod1tm1.1(SOD1)Emcf page

Germline Transmission:	Earliest citation of germline transmission: J:342505
Parent Cell Line:	R1 (ES Cell)
Strain of Origin:	(129X1/SvJ x 129S1/Sv)F1-Kitl+

Allele Type:    Targeted (Conditional ready, Humanized sequence, Null/knockout) Mutation:    Insertion   Mutation details: The mouse sequence is replaced with the human sequence that has a floxed duplication of exons 4 and 5. An FRT-flanked selection cassette was inserted downstream of the first human exon 5. Flp-mediated recombination removed the selection cassette and left the first set of human exon 4 and 5 floxed. (J:342505)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Sod1 Mutation:	37 strains or lines available

Original:	J:342505 Devoy A, et al., Generation and analysis of innovative genomically humanized knockin SOD1, TARDBP (TDP-43), and FUS mouse models. iScience. 2021 Dec 17;24(12):103463
All:	2 reference(s)