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Gene Expression Data
Assay Details
Assay
Reference: J:191972 Huang S, et al., Wls is expressed in the epidermis and regulates embryonic hair follicle induction in mice. PLoS One. 2012;7(9):e45904
Assay type: Immunohistochemistry
MGI Accession ID: MGI:6403100
Gene symbol: Wls
Gene name: wntless WNT ligand secretion mediator
Antibody: anti-Wls
Detection system: Secondary antibody coupled to Alexa Fluor 488
Results
Specimen 1A: embryonic day 13.5 (more )
Structure Level Pattern Image Note
TS21: epidermis Present 1A surface ectoderm
TS21: dermis Present 1A mesenchyme underlying the surface ectoderm
Specimen 1B: embryonic day 14.5 (more )
Structure Level Pattern Image Note
TS22: epidermis Present 1B
TS22: hair epidermal placode Present 1B
Specimen 1C: embryonic day 15.5 (more )
Structure Level Pattern Image Note
TS23: epidermis Present 1C
TS23: hair epidermal placode Present 1C
Specimen 1D: postnatal (more )
Note: anagen I stage
Structure Level Pattern Image Note
TS28: hair follicle bulge Strong 1D
TS28: hair follicle dermal papilla Present 1D
TS28: hair germ Present Regionally restricted 1D Expressed in the second hair germ, which connects the bulge and dermal papilla.
Specimen 1E: postnatal (more )
Note: anagen V stage
Structure Level Pattern Image Note
TS28: hair follicle matrix region Strong 1E keratinocyte matrix
TS28: hair shaft Strong 1E pre-hair shaft region
TS28: hair follicle dermal papilla Weak 1E
TS28: hair root sheath Absent 1E
Specimen 1F: postnatal (more )
Note: catagen I stage
Structure Level Pattern Image Note
TS28: hair inner root sheath Present 1F
TS28: hair outer root sheath Present 1F
TS28: hair shaft Present 1F
TS28: hair follicle dermal papilla Weak 1F
Specimen 1G: postnatal (more )
Note: catagen VI stage
Structure Level Pattern Image Note
TS28: hair follicle dermal papilla Present 1G Increased expression.
TS28: hair inner root sheath Present 1G Decreased expression.
TS28: hair outer root sheath Present 1G Decreased expression.
TS28: hair shaft Present 1G Decreased expression.
TS28: hair bulb Weak Regionally restricted 1G Expression was almost absent in the epithelial strand.
Specimen 1H: postnatal (more )
Note: catagen VII stage
Structure Level Pattern Image Note
TS28: hair follicle dermal papilla Present 1H
TS28: hair bulb Present Regionally restricted 1H Expressed in the lower part of hair follicles.
Specimen 1I: postnatal (more )
Note: telogen stage
Structure Level Pattern Image Note
TS28: hair follicle bulge Present 1I
TS28: hair follicle dermal papilla Present 1I relatively weak
Specimen 2H: embryonic day 13.5 (more )
Structure Level Pattern Image Note
TS21: epidermis Present 2H
Specimen 2I: embryonic day 13.5; Wlstm1Xzg/Wlstm1Xzg, Krt14tm1(cre)Wbm/Krt14+ (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS21: epidermis Trace 2I Significantly reduced expression compared with the wild-type control.
Specimen 2J: postnatal day 17 (more )
Structure Level Pattern Image Note
TS28: epidermis Present 2J
Specimen 2K: postnatal day 17; Wlstm1Xzg/Wlstm1Xzg, Krt14tm1(cre)Wbm/Krt14+ (more )
Note: Conditional mutant. hairless patches
Structure Level Pattern Image Note
TS28: epidermis Trace 2K Significantly reduced expression compared with the wild-type control.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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04/23/2024
MGI 6.23 		The Jackson Laboratory