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Gene Expression Data
Assay Details
Assay
Reference: J:266583 Baumgartner M, et al., Minor spliceosome inactivation causes microcephaly, owing to cell cycle defects and death of self-amplifying radial glial cells. Development. 2018 Aug 28;145(17):dev166322
Assay type: RNA in situ
MGI Accession ID: MGI:6400575
Gene symbol: Rnu11
Gene name: U11 small nuclear RNA
Probe: U11 probe1
Probe preparation: Antisense labelled with digoxigenin RNA
Visualized with: Alkaline phosphatase
Results
Specimen 1E Control: embryonic day 10.5; Rnu11tm1.1Rank/Rnu11+, Emx1tm1(cre)Krj/Emx1+ (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS17: telencephalon Present Regionally restricted 1E Control Expression was detected in the pallium.
Specimen 1E Mutant: embryonic day 10.5; Rnu11tm1.1Rank/Rnu11tm1.1Rank, Emx1tm1(cre)Krj/Emx1+ (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS17: telencephalon Weak Regionally restricted 1E Mutant Signal was reduced in the mutant pallium.
Specimen 1F Control: embryonic day 11.5; Rnu11tm1.1Rank/Rnu11+, Emx1tm1(cre)Krj/Emx1+ (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS20: neocortex Present 1F Control Expression was detected in the pallium.
Specimen 1F Mutant: embryonic day 11.5; Rnu11tm1.1Rank/Rnu11tm1.1Rank, Emx1tm1(cre)Krj/Emx1+ (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS20: neocortex Weak 1F Mutant The Rnu11-null domain was expanded in the E11 mutant pallium.
Specimen 1G Control: embryonic day 12.5; Rnu11tm1.1Rank/Rnu11+, Emx1tm1(cre)Krj/Emx1+ (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS20: neocortex Present 1G Control Expression was detected in the pallium.
Specimen 1G Mutant: embryonic day 12.5; Rnu11tm1.1Rank/Rnu11tm1.1Rank, Emx1tm1(cre)Krj/Emx1+ (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS20: neocortex Trace Scattered 1G Mutant By E12, the majority of cells in the Emx1-Cre domain lacked Rnu11 expression, with only scattered positive cells.
Specimen 1H Control: embryonic day 13.5; Rnu11tm1.1Rank/Rnu11+, Emx1tm1(cre)Krj/Emx1+ (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS21: neocortex Present 1H Control Expression was detected in the pallium.
Specimen 1H Mutant: embryonic day 13.5; Rnu11tm1.1Rank/Rnu11tm1.1Rank, Emx1tm1(cre)Krj/Emx1+ (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS21: neocortex Ambiguous 1H Mutant The Rnu11-null domain persisted at E13 in the Emx1-Cre domain .
Specimen 1I Control: embryonic day 14.5; Rnu11tm1.1Rank/Rnu11+, Emx1tm1(cre)Krj/Emx1+ (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS22: neocortex Present 1I Control Expression was detected in the pallium.
Specimen 1I Mutant: embryonic day 14.5; Rnu11tm1.1Rank/Rnu11tm1.1Rank, Emx1tm1(cre)Krj/Emx1+ (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS22: neocortex Ambiguous 1I Mutant
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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04/07/2026
MGI 6.24 		The Jackson Laboratory