Summary | Mutation origin | Mutation description | Recombinase activity | Find Mice (IMSR) | References

Symbol:	Ndnftm1.1(cre/ERT2)Ispgl
Name:	neuron-derived neurotrophic factor; targeted mutation 1.1, Ivo Spiegel
MGI ID:	MGI:6393601
Synonyms:	Ndnf-IRES-CreERT2
Gene:	Ndnf  Location: Chr6:65648595-65689307 bp, + strand  Genetic Position: Chr6, 30.29 cM
Alliance:	Ndnftm1.1(cre/ERT2)Ispgl page

Germline Transmission:	Earliest citation of germline transmission: J:268054
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	C57BL/6J

Allele Type:    Targeted (Inducible, Recombinase) Inducer:    tamoxifen Mutation:    Insertion   Ndnftm1.1(cre/ERT2)Ispgl expression driven by 1 gene Knock-in expression driven by: Organism Driver Gene Note mouse Ndnf (MGI:1915419)   Mutation details: The targeting vector was designed to insert an internal ribosome entry site (IRES) fused to a Cre/ERT2 fusion gene (Cre recombinase fused to a human estrogen receptor ligand binding domain) into the 3' UTR in exon 4 of the neuron-derived neurotrophic factor (Ndnf) gene. The construct also included a frt-flanked neomycin resistance cassette. After homologouse recombination in ES cells, the resulting chimeric mice were bred with flp recombinase expressing mice to remove the neo cassette. (J:268054)

Activity:	Tissue activity of this recombinase allele
Driver:	Ndnf (mouse) Summary of all recombinase alleles driven by Ndnf. Comparative matrix view of recombinase activities Alliance mouse Ndnf gene page

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Ndnf Mutation:	28 strains or lines available

Original:	J:268054 Abs E, et al., Learning-Related Plasticity in Dendrite-Targeting Layer 1 Interneurons. Neuron. 2018 Nov 7;100(3):684-699.e6
All:	2 reference(s)