Summary | Mutation origin | Mutation description | Find Mice (IMSR) | Notes | References

Symbol:	Col1a1tm1(tetO/CMV-Lep)Rll
Name:	collagen, type I, alpha 1; targeted mutation 1, Rudolph L Leibel
MGI ID:	MGI:6393313
Gene:	Col1a1  Location: Chr11:94827050-94843868 bp, + strand  Genetic Position: Chr11, 59.01 cM, cytoband D
Alliance:	Col1a1tm1(tetO/CMV-Lep)Rll page

Germline Transmission:	Earliest citation of germline transmission: J:283599
Parent Cell Line:	v6.5 (ES Cell)
Strain of Origin:	(C57BL/6 x 129S4/SvJae)F1

Allele Type:    Targeted (Inducible, Inserted expressed sequence) Inducer:    doxycycline/tetracycline Mutation:    Insertion   Mutation details: RCME on KH2 cells inserted a cassette that contains the tetracycline response element and CAG promoter driving inducible expression of the mouse Leptin gene followed by the hygromycin B selection gene. (J:283599)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Col1a1 Mutation:	160 strains or lines available

Original:	J:283599 Skowronski AA, et al., Physiological consequences of transient hyperleptinemia during discrete developmental periods on body weight in mice. Sci Transl Med. 2020 Jan 1;12(524)
All:	2 reference(s)