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Gene Expression Data
Assay Details
Assay
Reference: J:284359 Fillion ML, et al., Heterozygous loss-of-function mutation in Odd-skipped related 1 (Osr1) is associated with vesicoureteric reflux, duplex systems, and hydronephrosis. Am J Physiol Renal Physiol. 2017 Nov 1;313(5):F1106-F1115
Assay type: In situ reporter (knock in)
MGI Accession ID: MGI:6392886
Gene symbol: Osr1
Gene name: odd-skipped related transcription factor 1
Reporter: lacZ
Direct Detection
Assay notes: Fixed in a glutaraldehyde-formaldehyde solution.
Results
Specimen 5A: embryonic day 11.0; Osr1tm1Jian/Osr1+ (more )
Structure Level Pattern Image Note
TS18: 1st branchial arch mandibular component Present 5A Expression in mandibular process.
TS18: somite Present Regionally restricted 5A Expression in caudal somites.
TS18: trunk mesenchyme Present Regionally restricted 5A Expression in intermediate mesoderm
TS18: forelimb bud Present 5A
TS18: hindlimb bud Present 5A

Specimen 5B: embryonic day 11.0; Osr1tm1Jian/Osr1+ (more )
Note: Section at level of hindlimb.]
Structure Level Pattern Image Note
TS18: cloaca Present Regionally restricted 5B Expression surrounding cloaca.
TS18: genitourinary system Present Regionally restricted 5B Expression adjacent to nephric duct.

Specimen 5C: embryonic day 11.0; Osr1tm1Jian/Osr1+ (more )
Note: Section just posterior to level of forelimb.]
Structure Level Pattern Image Note
TS18: urogenital ridge Present 5C

Specimen 6A top: embryonic day 14.0; Osr1tm1Jian/Osr1+ (more )
Structure Level Pattern Image Note
TS22: urinary system Present 6A top

Specimen 6A middle: embryonic day 14.0; Osr1tm1Jian/Osr1+ (more )
Structure Level Pattern Image Note
TS22: ureteral mesenchyme Weak 6A middle Faint expression in ureteral mesenchyme

Specimen 6A bottom: embryonic day 14.0; Osr1tm1Jian/Osr1+ (more )
Structure Level Pattern Image Note
TS22: bladder Strong Regionally restricted 6A bottom Strong expression in uroepithelial layer of bladder, subepithelial layer and developing muscle layer.
TS22: detrusor muscle of bladder Strong 6A bottom
TS22: urothelium of bladder Strong 6A bottom

Specimen 6B top: embryonic day 16.0; Osr1tm1Jian/Osr1+ (more )
Structure Level Pattern Image Note
TS24: urinary system Present 6B top

Specimen 6B middle: embryonic day 16.0; Osr1tm1Jian/Osr1+ (more )
Structure Level Pattern Image Note
TS24: ureteral mesenchyme Present 6B middle

Specimen 6B bottom: embryonic day 16.0; Osr1tm1Jian/Osr1+ (more )
Structure Level Pattern Image Note
TS24: bladder Strong Regionally restricted 6B bottom Strong expression in uroepithelial layer of bladder, subepithelial layer and developing muscle layer.
TS24: detrusor muscle of bladder Strong 6B bottom
TS24: urothelium of bladder Strong 6B bottom

Specimen 6C top: postnatal newborn; Osr1tm1Jian/Osr1+ (more )
Structure Level Pattern Image Note
TS27: urinary system Present 6C top

Specimen 6C middle: postnatal newborn; Osr1tm1Jian/Osr1+ (more )
Structure Level Pattern Image Note
TS27: ureteral smooth muscle layer Strong 6C middle

Specimen 6C bottom: postnatal newborn; Osr1tm1Jian/Osr1+ (more )
Structure Level Pattern Image Note
TS27: bladder Strong Regionally restricted 6C bottom Strong expression in uroepithelial layer of bladder, subepithelial layer and developing muscle layer.
TS27: detrusor muscle of bladder Strong 6C bottom
TS27: urothelium of bladder Strong 6C bottom


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/18/2025
MGI 6.24
The Jackson Laboratory