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Gene Expression Data
Assay Details
Assay
Reference: J:171621 Kopecky B, et al., Conditional deletion of N-Myc disrupts neurosensory and non-sensory development of the ear. Dev Dyn. 2011 Jun;240(6):1373-90
Assay type: RNA in situ
MGI Accession ID: MGI:6392883
Gene symbol: Mycn
Gene name: v-myc avian myelocytomatosis viral related oncogene, neuroblastoma derived
Probe: N-Myc probe9
Probe preparation: Antisense labelled with digoxigenin RNA
Visualized with: Alkaline phosphatase
Results
Specimen 6A: embryonic day 10.5 (more )
Note: Fix: 0.4% paraformaldehyde.
Structure Level Pattern Image Note
TS17: ear Present Ubiquitous 6A

Specimen 6B: embryonic day 11.5 (more )
Note: Fix: 0.4% paraformaldehyde.
Structure Level Pattern Image Note
TS19: ear Present Ubiquitous 6B

Specimen 6C: embryonic day 12.5 (more )
Note: Fix: 0.4% paraformaldehyde.
Structure Level Pattern Image Note
TS20: inner ear epithelium Present Regionally restricted 6C , 6C' Expression was restricted to all sensory epithelia. Expression in the prosensory domains formed a base-to-apex gradient.
TS20: cochlea epithelium Present 6C'
TS20: saccule epithelium Strong 6C''
TS20: utricle epithelium Strong 6C''

Specimen 6D: embryonic day 13.5 (more )
Note: Fix: 0.4% paraformaldehyde.
Structure Level Pattern Image Note
TS21: semicircular canal Present Regionally restricted 6D' , 6D Expression was detected in the semicircular canal cristae.

Specimen 6E: embryonic day 14.5 (more )
Note: Fix: 0.4% paraformaldehyde.
Structure Level Pattern Image Note
TS22: cochlea Strong 6E , 6E'' , 6E'

Specimen 6E" inset: embryonic day 14.5 (more )
Note: Fix: 0.4% paraformaldehyde.
Structure Level Pattern Image Note
TS22: ductus reuniens Strong 6E'' inset
TS22: saccule Strong 6E'' inset

Specimen 6H: postnatal day 0 (more )
Note: Fix: 0.4% paraformaldehyde.
Structure Level Pattern Image Note
TS27: inner ear epithelium Strong Regionally restricted 6H Expression was detected in sensory epithelium.
TS27: organ of Corti Strong 6H' , 6H , 6H' inset
TS27: saccule Present 6H , 6H' inset , 6H'
TS27: utricle Present 6H , 6H' inset , 6H'

Specimen 6H inset: postnatal day 0 (more )
Note: Fix: 0.4% paraformaldehyde.
Structure Level Pattern Image Note
TS27: crista ampullaris Present Regionally restricted 6H inset Expression was detected in horizontal canal crista.

Specimen 6K: embryonic day 12.5 (more )
Note: Fix: 0.4% paraformaldehyde.
Structure Level Pattern Image Note
TS20: brain Present 6K

Specimen 6N WT: embryonic day 14.5 (more )
Note: Fix: 0.4% paraformaldehyde.
Structure Level Pattern Image Note
TS22: inferior colliculus Present 6N WT
TS22: rhombic lip Present 6N WT
TS22: pons Present Regionally restricted 6N WT Expression was detected in the cochlear nucleus.

Specimen 6N CKO: embryonic day 14.5; Mycntm1Psk/Mycntm1Psk, Tg(Pax2-cre)1Akg/0 (more )
Note: Conditional mutant. Fix: 0.4% paraformaldehyde.
Structure Level Pattern Image Note
TS22: inferior colliculus Absent 6N CKO
TS22: rhombic lip Absent 6N CKO
TS22: pons Absent 6N CKO Expression was not detected in the cochlear nucleus in the conditional mutant.


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/25/2025
MGI 6.24
The Jackson Laboratory