Summary | Mutation origin | Mutation description | Expression | Find Mice (IMSR) | References

Symbol:	Klf4em1Zfa
Name:	Kruppel-like transcription factor 4 (gut); endonuclease-mediated mutation 1, Zusen Fan
MGI ID:	MGI:6392146
Synonyms:	Klf4E381A
Gene:	Klf4  Location: Chr4:55527143-55532466 bp, - strand  Genetic Position: Chr4, 29.76 cM
Alliance:	Klf4em1Zfa page

Strain of Origin:

C57BL/6

Allele Type:    Endonuclease-mediated (Not Applicable) Mutation:    Nucleotide substitutions   Mutation details: CRISPR/Cas9 technology knocked-in a glutamate to alanine change at position 381 (E381A). This mutation produces a glutamylation-defective mutant. (J:259707)

In Mice Carrying this Mutation:

12 assay results

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Klf4 Mutation:	24 strains or lines available

Original:	J:259707 Ye B, et al., Klf4 glutamylation is required for cell reprogramming and early embryonic development in mice. Nat Commun. 2018 Mar 28;9(1):1261
All:	1 reference(s)