Summary | Mutation origin | Mutation description | Recombinase activity | Find Mice (IMSR) | References

Symbol:	Ighg3tm1.1(icre)Gbrt
Name:	Immunoglobulin heavy constant gamma 3; targeted mutation 1.1, Gregory M Barton
MGI ID:	MGI:6388414
Synonyms:	Ighg3T2A-Cre, Ighg3tm1.1(cre)Gbrt
Gene:	Ighg3  Location: Chr12:113321062-113324852 bp, - strand  Genetic Position: Chr12, 62.1 cM
Alliance:	Ighg3tm1.1(icre)Gbrt page

Germline Transmission:	Earliest citation of germline transmission: J:278686
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	C57BL/6

Allele Type:    Targeted (Recombinase) Mutation:    Insertion   Ighg3tm1.1(icre)Gbrt expression driven by 1 gene Knock-in expression driven by: Organism Driver Gene Note mouse Ighg3 (MGI:2144790)   Mutation details: The allele was generated by constructing a targeting vector encoding the self-cleaving peptide T2A followed by the iCre gene and a frt-flanked neomycin resistance gene to be inserted immediately 3' of the last Ighg3 transmembrane exon. The neo cassette was removed by Flp-mediated recombination in the chimeric mice. (J:278686)

Activity:	Tissue activity of this recombinase allele
Driver:	Ighg3 (mouse) Summary of all recombinase alleles driven by Ighg3. Alliance mouse Ighg3 gene page

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Ighg3 Mutation:	13 strains or lines available

Original:	J:278686 Kreuk LS, et al., B cell receptor and Toll-like receptor signaling coordinate to control distinct B-1 responses to both self and the microbiota. Elife. 2019 Aug 21;8:e47015
All:	1 reference(s)