Summary | Mutation origin | Mutation description | Recombinase activity | Find Mice (IMSR) | References

Symbol:	Gt(ROSA)26Sortm7(CAG-dre/ERT2)Bzsh
Name:	gene trap ROSA 26, Philippe Soriano; targeted mutation 7, Bin Zhou
MGI ID:	MGI:6388407
Synonyms:	R26-LDLZ
Gene:	Gt(ROSA)26Sor  Location: Chr6:113044389-113054205 bp, - strand  Genetic Position: Chr6, 52.73 cM
Alliance:	Gt(ROSA)26Sortm7(CAG-dre/ERT2)Bzsh page

Germline Transmission:	Earliest citation of germline transmission: J:278877
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	Not Specified

Allele Type:    Targeted (Conditional ready, Inducible, Recombinase, Reporter) Inducer:    tamoxifen Mutation:    Insertion   Gt(ROSA)26Sortm7(CAG-dre/ERT2)Bzsh expression driven by 1 gene Knock-in expression driven by: Organism Driver Gene Note chicken CAG   Mutation details: A Rosa-CAG targeting vector was designed to insert cassette containing (from 5' to 3') a CMV-IE enhancer/chicken beta-actin/rabbit beta-globin hybrid promoter (CAG), loxP-site, Dre recombinase fused with a mutant form of estrogen receptor hormon-binding domaine C (ERT2), STOP cassette (with stop codons in all 3 reading frames and a triple polyA signal), second loxP-site, ZsGreen sequence (an enhanced green fluorescent protein engineered for brighter fluorescence and higher expression in mammalian cells), WPRE (woodchuck hepatitis virus posttranscriptional regulatory element)-polyA, and Frt flanked neomicyne selection cassette (CAG-loxp-DreERT2-stop-loxp-ZsGreen-polyA-Frt-Neo-Frt) into the Rosa26 locus. (J:278877)

Activity:	Tissue activity of this recombinase allele
Driver:	CAG (chicken) Summary of all recombinase alleles driven by CAG.

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Gt(ROSA)26Sor Mutation:	944 strains or lines available

Original:	J:278877 Li Y, et al., Genetic Tracing Identifies Early Segregation of the Cardiomyocyte and Nonmyocyte Lineages. Circ Res. 2019 Jul 19;125(3):343-355
All:	5 reference(s)