Tnni3em1(dre)Bzsh
Endonuclease-mediated Allele Detail
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Symbol: |
Tnni3em1(dre)Bzsh |
Name: |
troponin I, cardiac 3; endonuclease-mediated mutation 1, Bin Zhou |
MGI ID: |
MGI:6386758 |
Synonyms: |
Tnni3-Dre |
Gene: |
Tnni3 Location: Chr7:4521304-4526228 bp, - strand Genetic Position: Chr7, 2.61 cM
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Alliance: |
Tnni3em1(dre)Bzsh page
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Strain of Origin: |
Not Specified
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Allele Type: |
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Endonuclease-mediated (Recombinase) |
Mutation: |
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Insertion
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Tnni3em1(dre)Bzsh expression driven by
1 gene
Knock-in expression driven by:
Organism |
Driver Gene |
Note |
mouse |
Tnni3 (MGI:98783) |
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Mutation details: A cDNA encoding Dre recombinase was iserted into the site encoding the translational start codon of the Krt19 gene, using the CRISPR/Cas9 technology. The woodchuck hepatitis virus post-transcriptional regulatory element (WPRE) were placed after the Dre cDNA sequence to stabilize the Dre-encoding mRNA.
(J:278073)
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Activity: |
Tissue activity of this recombinase allele
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Driver:
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Tnni3
(mouse)
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any Tnni3 Mutation: |
14 strains or lines available
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Original: |
J:278073 He L, et al., Enhancing the precision of genetic lineage tracing using dual recombinases. Nat Med. 2017 Dec;23(12):1488-1498 |
All: |
6 reference(s) |
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