Summary | Mutation origin | Mutation description | Recombinase activity | Find Mice (IMSR) | References

Symbol:	Tlr2tm2(cre/ERT2)Dfil
Name:	toll-like receptor 2; targeted mutation 2, Dominik Filipp
MGI ID:	MGI:6385317
Synonyms:	Tlr2CreERT2
Gene:	Tlr2  Location: Chr3:83743579-83749045 bp, - strand  Genetic Position: Chr3, 37.4 cM
Alliance:	Tlr2tm2(cre/ERT2)Dfil page

Germline Transmission:	Earliest citation of germline transmission: J:281617
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	Not Specified

Allele Type:    Targeted (Inducible, Recombinase) Inducer:    tamoxifen Mutation:    Insertion   Tlr2tm2(cre/ERT2)Dfil expression driven by 1 gene Knock-in expression driven by: Organism Driver Gene Note mouse Tlr2 (MGI:1346060)   Mutation details: The targeting vector is designed to insert Cre/ERT2 cassettes under the control of the Tlr2 promoter by BAC recombineering. After homologous recombination in ES cells, open reading frame of Tlr2 exon 3 was substituted with Cre/ERT2. (J:281617)

Activity:	Tissue activity of this recombinase allele
Driver:	Tlr2 (mouse) Summary of all recombinase alleles driven by Tlr2. Alliance mouse Tlr2 gene page

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Tlr2 Mutation:	56 strains or lines available

Original:	J:281617 Balounova J, et al., Toll-like receptor 2 expression on c-kit(+) cells tracks the emergence of embryonic definitive hematopoietic progenitors. Nat Commun. 2019 Nov 15;10(1):5176
All:	1 reference(s)