Summary | Mutation origin | Mutation description | Expression | Recombinase activity | Find Mice (IMSR) | References

Symbol:	Fgf18tm2.2(cre/ERT2)Dor
Name:	fibroblast growth factor 18; targeted mutation 2.2, David M Ornitz
MGI ID:	MGI:6382298
Synonyms:	Fgf18CreERT2
Gene:	Fgf18  Location: Chr11:33067430-33097400 bp, - strand  Genetic Position: Chr11, 19.21 cM
Alliance:	Fgf18tm2.2(cre/ERT2)Dor page

Germline Transmission:	Earliest citation of germline transmission: J:279323
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	Not Specified

Allele Type:    Targeted (Inducible, Null/knockout, Recombinase, Reporter) Inducer:    tamoxifen Mutations:    Insertion, Intragenic deletion   Fgf18tm2.2(cre/ERT2)Dor expression driven by 1 gene Knock-in expression driven by: Organism Driver Gene Note mouse Fgf18 (MGI:1277980)   Mutation details: A multifunctional targeting vector inserted a splice acceptor (SA)-eGFP:CreERT2 fusion gene into the intron located between Fgf18 exons 1B and 1C along with a PGK-neo selection cassette. Additional Frt and LoxP recombination sites were placed in the targeted allele to allow the generation of two independent alleles by crossing the parental mouse line to either a germline expressed FLP recombinase or a germline expressed Cre recombinase mouse. This generated a tamoxifen inducible eGFP:CreERT2 allele driven by the endogenous Fgf18 promoter (Fgf18CreERT2) that can be used for lineage tracing. The Fgf18CreERT2 allele has exon 1C deleted and is predicted to behave as a functional null allele. (J:279323)

Activity:	Tissue activity of this recombinase allele
Driver:	Fgf18 (mouse) Summary of all recombinase alleles driven by Fgf18. Comparative matrix view of recombinase activities Alliance mouse Fgf18 gene page

In Mice Carrying this Mutation:

16 assay results

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Fgf18 Mutation:	10 strains or lines available

Original:	J:279323 Hagan AS, et al., Generation and validation of novel conditional flox and inducible Cre alleles targeting fibroblast growth factor 18 (Fgf18). Dev Dyn. 2019 Sep;248(9):882-893
All:	3 reference(s)