Summary | Mutation origin | Mutation description | Recombinase activity | Find Mice (IMSR) | References

Symbol:	Gdf15tm1(cre/ERT2)Amc
Name:	growth differentiation factor 15; targeted mutation 1, Andrew P McMahon
MGI ID:	MGI:6382101
Synonyms:	Gdf15nuGFP-CE
Gene:	Gdf15  Location: Chr8:71082043-71085106 bp, - strand  Genetic Position: Chr8, 34.15 cM, cytoband C1
Alliance:	Gdf15tm1(cre/ERT2)Amc page

Germline Transmission:	Earliest citation of germline transmission: J:294071
Parent Cell Line:	JM8A1.N3 (ES Cell)
Strain of Origin:	C57BL/6N-Atm1Brd

Allele Type:    Targeted (Inducible, Recombinase) Inducer:    tamoxifen Mutation:    Insertion   Gdf15tm1(cre/ERT2)Amc expression driven by 1 gene Knock-in expression driven by: Organism Driver Gene Note mouse Gdf15 (MGI:1346047)   Mutation details: Recombinase mediated cassette exchange (RMCE) replaced the fragment between FRT and the third loxP which contained lacZ , neomycin and exon 2 sequences located in intron 1 of the Gdf15 allele with the following - an FRT site, En2 splice acceptor, P2A, nuclear GFP, F2A, cre/ERT2, polyA and a rox-flanked puromycin resistance cassette followed by a loxP site. (J:101977, J:294071)

Activity:	Tissue activity of this recombinase allele
Driver:	Gdf15 (mouse) Summary of all recombinase alleles driven by Gdf15. Comparative matrix view of recombinase activities Alliance mouse Gdf15 gene page

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Gdf15 Mutation:	26 strains or lines available

Original:	J:294071 Liu J, et al., Renoprotective and Immunomodulatory Effects of GDF15 following AKI Invoked by Ischemia-Reperfusion Injury. J Am Soc Nephrol. 2020 Apr;31(4):701-715
All:	2 reference(s)