Summary | Mutation origin | Mutation description | Recombinase activity | Find Mice (IMSR) | References

Symbol:	Aqp2tm1(cre/ERT2)Wezh
Name:	aquaporin 2; targeted mutation 1, Wenzheng Zhang
MGI ID:	MGI:6382079
Synonyms:	Aqp2ECE
Gene:	Aqp2  Location: Chr15:99476937-99482426 bp, + strand  Genetic Position: Chr15, 56.13 cM
Alliance:	Aqp2tm1(cre/ERT2)Wezh page

Germline Transmission:	Earliest citation of germline transmission: J:281293
Parent Cell Line:	JM8.N4 (ES Cell)
Strain of Origin:	C57BL/6N

Allele Type:    Targeted (Inducible, Recombinase) Inducer:    tamoxifen Mutation:    Insertion   Aqp2tm1(cre/ERT2)Wezh expression driven by 1 gene Knock-in expression driven by: Organism Driver Gene Note mouse Aqp2 (MGI:1096865)   Mutation details: The cre recombinase gene is flanked by 2 ERT2 ligand binding domains, an ECE cassette, followed by a bovine growth hormone polyadenylation signal and neo-selection cassette were inserted into mouse genome at the ATG of the endogenous Aqp2 locus. (J:281293)

Activity:	Tissue activity of this recombinase allele
Driver:	Aqp2 (mouse) Summary of all recombinase alleles driven by Aqp2. Comparative matrix view of recombinase activities Alliance mouse Aqp2 gene page

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Aqp2 Mutation:	17 strains or lines available

Original:	J:281293 Chen L, et al., Highly tamoxifen-inducible principal cell-specific Cre mice with complete fidelity in cell specificity and no leakiness. Am J Physiol Renal Physiol. 2018 Apr 1;314(4):F572-F583
All:	1 reference(s)