Summary | Mutation origin | Mutation description | Find Mice (IMSR) | References

Symbol:	Gabra2C57BL/6J+em1Geh
Name:	gamma-aminobutyric acid type A receptor subunit alpha 2; endonuclease-mediated revertant 1, Gregg E Homanics
MGI ID:	MGI:6381661
Synonyms:	Gabra2em1Geh, Gabra2KI, Rr126C57BL/6J+em1Geh
Gene:	Gabra2  Location: Chr5:71115735-71253192 bp, - strand  Genetic Position: Chr5, 37.59 cM
Alliance:	Gabra2C57BL/6J+em1Geh page

Strain of Origin:

C57BL/6J

Allele Type:    Endonuclease-mediated (Modified regulatory region) Mutations:    Insertion, Single point mutation   Mutation details: CRISPR/Cas9 was used to insert a single base pair (A on negative strand) between Chr5:71,014,638-639 to correct the spontaneous deletion of an A in intron 4 that is inherent in C57BL/6J and BXD40. This restores the allele to the "wild-type" form as found in C57BL/6NJ, C57BL/6ByJ, C57BL/6EiJ, DBA/2J and others. (J:280223) Inheritance:    Dominant

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Gabra2 Mutation:	34 strains or lines available

Original:	J:280223 Mulligan MK, et al., Identification of a Functional Non-coding Variant in the GABA A Receptor alpha2 Subunit of the C57BL/6J Mouse Reference Genome: Major Implications for Neuroscience Research. Front Genet. 2019;10:188
All:	3 reference(s)