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Gene Expression Data
Assay Details
Assay
Reference: J:127540 Margagliotti S, et al., The Onecut transcription factors HNF-6/OC-1 and OC-2 regulate early liver expansion by controlling hepatoblast migration. Dev Biol. 2007 Nov 15;311(2):579-89
Assay type: In situ reporter (knock in)
MGI Accession ID: MGI:6379794
Gene symbol: Onecut2
Gene name: one cut domain, family member 2
Reporter: lacZ
Direct Detection
Results
Specimen 1A: embryonic day 10.5; Onecut2tm1Flem/Onecut2+ (more )
Structure Level Pattern Image Note
TS17: liver Present 1A No significant changes in liver morphology compared to control embryos.
Specimen 1B: embryonic day 10.5; Onecut1tm1Flem/Onecut1+, Onecut2tm1Flem/Onecut2tm1Flem (more )
Structure Level Pattern Image Note
TS17: liver Present 1B No significant changes in liver morphology compared to control embryos.
Specimen 1C: embryonic day 10.5; Onecut1tm1Flem/Onecut1tm1Flem, Onecut2tm1Flem/Onecut2+ (more )
Structure Level Pattern Image Note
TS17: liver Present 1C Liver was strongly hypoplastic.
Specimen 1D: embryonic day 10.5; Onecut1tm1Flem/Onecut1tm1Flem, Onecut2tm1Flem/Onecut2tm1Flem (more )
Structure Level Pattern Image Note
TS17: liver Present 1D Liver was strongly hypoplastic.
Specimen 1E: embryonic day 9.5; Onecut2tm1Flem/Onecut2+ (more )
Note: 26 somites
Structure Level Pattern Image Note
TS15: hepatic primordium Present 1E
Specimen 1F: embryonic day 9.5; Onecut1tm1Flem/Onecut1+, Onecut2tm1Flem/Onecut2tm1Flem (more )
Note: 26 somites
Structure Level Pattern Image Note
TS15: hepatic primordium Present 1F
Specimen 1G: embryonic day 9.5; Onecut1tm1Flem/Onecut1tm1Flem, Onecut2tm1Flem/Onecut2+ (more )
Note: 26 somites
Structure Level Pattern Image Note
TS15: hepatic primordium Present 1G Liver bud is hypoplastic and less irregular compared to control.
Specimen 1H: embryonic day 9.5; Onecut1tm1Flem/Onecut1tm1Flem, Onecut2tm1Flem/Onecut2tm1Flem (more )
Note: 26 somites
Structure Level Pattern Image Note
TS15: hepatic primordium Present 1H Liver bud is hypoplastic and less irregular compared to control.
Specimen 1I: embryonic day 9.0; Onecut2tm1Flem/Onecut2+ (more )
Note: 18 somites
Structure Level Pattern Image Note
TS14: hepatic primordium Present 1I
Specimen 1J: embryonic day 9.0; Onecut1tm1Flem/Onecut1tm1Flem, Onecut2tm1Flem/Onecut2+ (more )
Note: 18 somites
Structure Level Pattern Image Note
TS14: hepatic primordium Present 1J No evidence of liver hypoplasia.
Specimen 1K: embryonic day 9.0; Onecut1tm1Flem/Onecut1tm1Flem, Onecut2tm1Flem/Onecut2tm1Flem (more )
Note: 17 somites
Structure Level Pattern Image Note
TS14: hepatic primordium Present 1K No evidence of liver hypoplasia.
Specimen 3A: embryonic day 9.5; Onecut2tm1Flem/Onecut2+ (more )
Note: 26 somites
Structure Level Pattern Image Note
TS15: hepatic primordium Present Regionally restricted 3A Hepatoblasts migrate out of liver bud and invade septum transversum mesenchyme.
TS15: septum transversum Present Regionally restricted 3A Hepatoblasts migrate out of liver bud and invade septum transversum mesenchyme.
Specimen 3B: embryonic day 9.5; Onecut1tm1Flem/Onecut1+, Onecut2tm1Flem/Onecut2tm1Flem (more )
Note: 25 somites
Structure Level Pattern Image Note
TS15: hepatic primordium Present Regionally restricted 3B Hepatoblasts migrate out of liver bud and invade septum transversum mesenchyme.
TS15: septum transversum Present Regionally restricted 3B Hepatoblasts migrate out of liver bud and invade septum transversum mesenchyme.
Specimen 3C: embryonic day 9.5; Onecut1tm1Flem/Onecut1tm1Flem, Onecut2tm1Flem/Onecut2+ (more )
Note: 26 somites
Structure Level Pattern Image Note
TS15: hepatic primordium Present Regionally restricted 3C Authors report delamination of hepatoblasts was impaired.
TS15: septum transversum Ambiguous 3C Invasion of septum transversum mesenchyme was impaired.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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04/30/2024
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