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Gene Expression Data
Assay Details
Assay
Reference: J:122558 Yu L, et al., Shox2 is required for chondrocyte proliferation and maturation in proximal limb skeleton. Dev Biol. 2007 Jun 15;306(2):549-59
Assay type: RNA in situ
MGI Accession ID: MGI:6377421
Gene symbol: Runx2
Gene name: runt related transcription factor 2
Probe: Runx2 cDNA8
Probe preparation: Antisense labelled with digoxigenin RNA
Results
Specimen 5A: embryonic day 11.5 (more )
Structure Level Pattern Image Note
TS19: future arm mesenchyme Present Regionally restricted 5A Expression restricted to central portions mesenchymal chondrogenic condensations.
Specimen 5B: embryonic day 11.5; Shox2tm1Ypc/Shox2tm1Ypc (more )
Structure Level Pattern Image Note
TS19: future arm mesenchyme Weak Regionally restricted 5B Expression dramatically down-regulated in humerus condensation. Expression remains similar in zeugopod.
Specimen 5E: embryonic day 12.5 (more )
Structure Level Pattern Image Note
TS20: humerus pre-cartilage condensation Present 5E
TS20: radius-ulna pre-cartilage condensation Present 5E
Specimen 5F: embryonic day 12.5; Shox2tm1Ypc/Shox2tm1Ypc (more )
Structure Level Pattern Image Note
TS20: humerus pre-cartilage condensation Trace 5F Expression almost completely absent in humerus.
TS20: radius-ulna pre-cartilage condensation Present 5F
Specimen 5I: embryonic day 13.5 (more )
Structure Level Pattern Image Note
TS21: humerus cartilage condensation Present Regionally restricted 5I Expression restricted to pre- and early hypertrophic chondrocytes.
TS21: upper arm rest of mesenchyme Present Regionally restricted 5I Expression in perichondrium.
Specimen 5J: embryonic day 13.5; Shox2tm1Ypc/Shox2tm1Ypc (more )
Structure Level Pattern Image Note
TS21: humerus cartilage condensation Absent 5J
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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03/25/2025
MGI 6.24 		The Jackson Laboratory