Gene Expression Data
Assay Details
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Assay
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Reference:
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J:164931
Sirmaci A, et al., A truncating mutation in SERPINB6 is associated with autosomal-recessive nonsyndromic sensorineural hearing loss. Am J Hum Genet. 2010 May 14;86(5):797-804
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Assay type:
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Immunohistochemistry
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MGI Accession ID:
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MGI:6377126
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Gene symbol:
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Serpinb6a
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Gene name:
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serine (or cysteine) peptidase inhibitor, clade B, member 6a
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Antibody:
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Anti-SerpinB6 (F-12; sc-21143)
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Detection system:
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Secondary antibody coupled to Alexa Fluor 594
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Assay notes:
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Authors indicated that the human SERPINB6 antibody recognizes mouse Serpinb6a and Serpinb6c. Mouse Serpinb6a has the highest homology to human SERPINB6 with 75% identity, whereas Serpinb6c is 68% identical to SERPINB6. Only Serpinb6a has been annotated.
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Results
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Specimen
2A:
embryonic day 13.5
(more  )
Specimen
2A:
(close  )
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Genetic Background:
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Not Specified
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Age:
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embryonic day 13.5
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Sex:
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Not Specified
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Type:
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section
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Embedding:
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Cryosection
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| Structure |
Level |
Pattern |
Image |
Note |
| TS21: utricle epithelium |
Weak |
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2D
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2A
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Weak expression was detected in utricular sensory epithelium. However, expression was not in utricular hair cells.
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Specimen
2E:
embryonic day 16.5
(more )
Specimen
2E:
(close )
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Genetic Background:
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Not Specified
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Age:
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embryonic day 16.5
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Sex:
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Not Specified
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Type:
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section
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Embedding:
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Cryosection
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| Structure |
Level |
Pattern |
Image |
Note |
| TS24: semicircular canal |
Present |
Regionally restricted |
2E
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2H
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Distinct expression was detected in crista hair cells.
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Specimen
2I:
embryonic day 16.5
(more )
Specimen
2I:
(close )
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Genetic Background:
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Not Specified
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Age:
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embryonic day 16.5
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Sex:
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Not Specified
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Type:
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section
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Embedding:
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Cryosection
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| Structure |
Level |
Pattern |
Image |
Note |
| TS24: cochlea |
Weak |
Regionally restricted |
2L
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2I
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Weak expression was detected in cochlear hair cells.
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Specimen
2M:
postnatal day 6
(more )
Specimen
2M:
(close )
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Genetic Background:
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Not Specified
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Age:
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postnatal day 6
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Sex:
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Not Specified
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Type:
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section
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Embedding:
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Cryosection
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| Structure |
Level |
Pattern |
Image |
Note |
| TS28: cochlea |
Present |
Regionally restricted |
2M
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2P
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Expression was upregulated in P6 inner and outer hair cells, with mainly cytoplasmic distribution.
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| TS28: cochlea epithelium |
Present |
Regionally restricted |
2M
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2P
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Expression was detected in the greater epithelial ridge.
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Analysis Tools