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Gene Expression Data
Assay Details
Assay
Reference: J:276152 Horton AJ, et al., Nkx2-5 Second Heart Field Target Gene Ccdc117 Regulates DNA Metabolism and Proliferation. Sci Rep. 2019 Feb 11;9(1):1738
Assay type: RNA in situ
MGI Accession ID: MGI:6377099
Gene symbol: Ccdc117
Gene name: coiled-coil domain containing 117
Probe: Ccdc117 cDNA1
Probe preparation: Antisense labelled with digoxigenin RNA
Visualized with: Alkaline phosphatase
Results
Specimen 1A: embryonic day 8.5 (more )
Structure Level Pattern Image Note
TS13: 1st branchial arch Present Regionally restricted 1A Expression is seen near the aortic pole of the heart.
TS13: outflow tract Present Regionally restricted 1A Expression is seen near the venous pole of the heart.

Specimen 1D: embryonic day 8.75 (more )
Structure Level Pattern Image Note
TS14: branchial arch Present Regionally restricted 1D Expression is seen near the aortic pole of the heart.
TS14: mesenchyme derived from splanchnopleure Present Regionally restricted 1D Expression is seen near the venous pole of the heart.
TS14: outflow tract Present Regionally restricted 1D Expression is seen near the venous pole of the heart.

Specimen 1B: embryonic day 9.5 (more )
Structure Level Pattern Image Note
TS15: branchial arch mesenchyme Present Regionally restricted 1B Expression is seen in the secondary heart field-containing pharyngeal arch tissue.
TS15: secondary heart field Present 1B
TS15: primitive ventricle Present Regionally restricted 1B Expression is seen in the developing right ventricle.
TS15: heart atrium Present Regionally restricted 1B Expression is seen in the developing right atrium.
TS15: outflow tract Present 1B
TS15: head Present Regionally restricted 1B Expression is seen in lower craniofacial regions.

Specimen 1E: embryonic day 9.5 (more )
Structure Level Pattern Image Note
TS15: branchial arch mesenchyme Present Regionally restricted 1E Expression is seen in the secondary heart field-containing pharyngeal arch tissue.
TS15: secondary heart field Present 1E
TS15: outflow tract Present 1E

Specimen not shown: embryonic day 9.5 (more )
Structure Level Pattern Image Note
TS15: branchial arch endoderm Present
TS15: outflow tract endocardial tube Present Expression is seen in the outflow tract endocardium.
TS15: central nervous system Present Regionally restricted Expression is seen in ventral neural tube populations.

Specimen not shown: embryonic day 12.5 (more )
Structure Level Pattern Image Note
TS20: embryo Present Expression is seen in multiple tissues.

Specimen 1C: embryonic day 9.5; Nkx2-5tm4Rph/Nkx2-5tm4Rph (more )
Structure Level Pattern Image Note
TS15: branchial arch mesenchyme Present Regionally restricted 1C Expression levels are greatly reduced in the secondary heart field-containing pharyngeal arch tissue.
TS15: branchial arch endoderm Present 1C Expression levels are greatly reduced in the mutant.
TS15: outflow tract Present 1C Expression levels are greatly reduced in the mutant.
TS15: secondary heart field Present 1C Expression levels are greatly reduced in the mutant.
TS15: head mesenchyme Present Regionally restricted 1C Expression is retained in craniofacial mesoderm.
TS15: heart atrium Present 1C Expression is retained in the atria.
TS15: mesenchyme derived from splanchnopleure Present Regionally restricted 1C Expression is retained in the posterior spanchnic mesoderm.
TS15: outflow tract endocardial tube Absent 1C
TS15: central nervous system Present Regionally restricted 1C Expression is retained in the ventral portions of the neural tube.

Specimen 1F: embryonic day 9.5; Nkx2-5tm4Rph/Nkx2-5tm4Rph (more )
Structure Level Pattern Image Note
TS15: branchial arch mesenchyme Present Regionally restricted 1F Expression levels are greatly reduced in the secondary heart field-containing pharyngeal arch tissue.
TS15: outflow tract Present 1F Expression levels are greatly reduced in the mutant.
TS15: secondary heart field Present 1F Expression levels are greatly reduced in the mutant.


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
04/23/2024
MGI 6.23
The Jackson Laboratory