Summary | Mutation origin | Mutation description | Find Mice (IMSR) | References

Symbol:	Ren1tm2.2Sig
Name:	renin 1 structural; targeted mutation 2.2, Curt Sigmund
MGI ID:	MGI:6368628
Synonyms:	renin-bnull
Gene:	Ren1  Location: Chr1:133278412-133288058 bp, + strand  Genetic Position: Chr1, 57.91 cM
Alliance:	Ren1tm2.2Sig page

Germline Transmission:	Earliest citation of germline transmission: J:278974
Parent Cell Line:	iTL IC1 (ES Cell)
Strain of Origin:	C57BL/6NTac

Allele Type:    Targeted (Modified isoform(s)) Mutations:    Insertion, Intragenic deletion   Mutation details: An FRT-flanked neomycin resistance cassette with a 5' loxP site was inserted upstream of exon 1b. An additional loxP site was inserted downstream of exon 1b. Flp-mediated recombination removed the selection cassette. Cre-mediated recombination removed exon 1b. Mice fail to express the brain isoform (renin-b), but express the kideny isoform (renin-a). (J:278974)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Ren1 Mutation:	36 strains or lines available

Original:	J:278974 Shinohara K, et al., Selective Deletion of the Brain-Specific Isoform of Renin Causes Neurogenic Hypertension. Hypertension. 2016 Dec;68(6):1385-1392
All:	4 reference(s)