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Gene Expression Data
Assay Details
Assay
Reference: J:124920 Garrison WD, et al., Hepatocyte nuclear factor 4alpha is essential for embryonic development of the mouse colon. Gastroenterology. 2006 Apr;130(4):1207-20
Assay type: Immunohistochemistry
MGI Accession ID: MGI:6368521
Gene symbol: Hnf4a
Gene name: hepatic nuclear factor 4, alpha
Results
Specimen 1A: embryonic day 9.5 (more )
Structure Level Pattern Image Note
TS15: hepatic primordium Present 1A
TS15: hindgut epithelium Present 1A
TS15: midgut epithelium Present 1A
TS15: foregut Absent 1A

Specimen 1B: embryonic day 9.5 (more )
Structure Level Pattern Image Note
TS15: hepatic primordium Present 1B
TS15: hindgut epithelium Present 1B
TS15: midgut epithelium Present 1B
TS15: foregut Absent 1B

Specimen 1C: embryonic day 11.5 (more )
Structure Level Pattern Image Note
TS19: stomach epithelium Present Regionally restricted 1C Expression is in the epithelium of the lower intestinal tract with a sharp rostral boundary in the stomach.
TS19: gut epithelium Present 1C

Specimen 1D: embryonic day 11.5 (more )
Structure Level Pattern Image Note
TS19: gut epithelium Present 1D
TS19: small intestine epithelium Present 1D

Specimen 1E: embryonic day 14.5 (more )
Structure Level Pattern Image Note
TS22: small intestine epithelium Present 1E

Specimen 1F: embryonic day 15.5 (more )
Structure Level Pattern Image Note
TS23: small intestine epithelium Present 1F

Specimen 1G: embryonic day 17.5 (more )
Structure Level Pattern Image Note
TS25: small intestine epithelium Present 1G

Specimen 1H: embryonic day 17.5 (more )
Structure Level Pattern Image Note
TS25: colon epithelium Present 1H

Specimen 2C: embryonic day 18.5; Hnf4atm1Sad/Hnf4a+, Tg(Foxa3-cre)1Khk/0 (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS26: colon epithelium Present 2C Expression is in the nuclei.

Specimen 2D: embryonic day 18.5; Hnf4atm1Sad/Hnf4atm1Sad, Tg(Foxa3-cre)1Khk/0 (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS26: colon epithelium Present Regionally restricted 2D Some mutant colons displayed a chimeric expression with <10% of the mice having complete absence of expression (shown).

Specimen 2E: embryonic day 18.5; Hnf4atm1Sad/Hnf4atm1Sad, Tg(Foxa3-cre)1Khk/0 (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS26: colon epithelium Present Regionally restricted 2E Some mutant colons displayed a chimeric expression with <10% of the mice having complete absence of expression.

Specimen 2F: embryonic day 18.5; Hnf4atm1Sad/Hnf4atm1Dnl, Tg(Foxa3-cre)1Khk/0 (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS26: colon epithelium Absent 2F About 40% of the mice had undetectable levels of expression.

Specimen not shown: postnatal adult; Hnf4atm1Sad/Hnf4atm1Dnl, Tg(Foxa3-cre)1Khk/0 (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS28: large intestine epithelium Present
TS28: small intestine epithelium Present


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/25/2025
MGI 6.24
The Jackson Laboratory