Rbbp8Sum6-Jus
Chemically induced Allele Detail
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| Symbol: |
Rbbp8Sum6-Jus |
| Name: |
retinoblastoma binding protein 8, endonuclease; suppressor of methyl CpG binding protein 2-6, 1 Monica J Justice |
| MGI ID: |
MGI:6367664 |
| Synonyms: |
Line 895 |
| Gene: |
Rbbp8 Location: Chr18:11766333-11876264 bp, + strand Genetic Position: Chr18, 5.85 cM
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| Alliance: |
Rbbp8Sum6-Jus page
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| Allele Type: |
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Chemically induced (ENU) (Not Specified) |
| Mutation: |
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Translocation
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Mutation details:
This allele was discovered in a screen for attenuation of the Mecp2tm1.1Bird/Y phenotype among male G1 offspring from crosses of 129S-Mecp2tm1.1Bird/+ female mice by ENU-treated C57BL/6J males (G0). The mutation has been identified as a C to T resulting in the amino acid substitution of a stop codon for glutamine at position 743 (exon15:c.2227C>T:p.Q743X (895)).
(J:323637)
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| Inheritance: |
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Other (see notes) |
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| Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
| Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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| Carrying any Rbbp8 Mutation: |
51 strains or lines available
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| Original: |
J:323637 Enikanolaiye A, et al., Suppressor mutations in Mecp2-null mice implicate the DNA damage response in Rett syndrome pathology. Genome Res. 2020 Apr;30(4):540-552 |
| All: |
1 reference(s) |
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Analysis Tools
