Summary | Mutation origin | Mutation description | Recombinase activity | Find Mice (IMSR) | References

Symbol:	Kitem1(cre)Bzsh
Name:	KIT proto-oncogene receptor tyrosine kinase; endonuclease-mediated mutation 1, Bin Zhou
MGI ID:	MGI:6361908
Synonyms:	Kit-2A-Cre
Gene:	Kit  Location: Chr5:75735647-75817382 bp, + strand  Genetic Position: Chr5, 39.55 cM
Alliance:	Kitem1(cre)Bzsh page

Strain of Origin:

C57BL/6J

Allele Type:    Endonuclease-mediated (Recombinase) Mutation:    Insertion   Kitem1(cre)Bzsh expression driven by 1 gene Knock-in expression driven by: Organism Driver Gene Note mouse Kit (MGI:96677)   Mutation details: The mouse line was generated by homologous recombination using the CRISPR/Cas9 technology. A self-cleaving 2A peptide and complementary DNA encoding Cre recombinase replaced the translational stop codon and inserted in Kit gene. (J:278090)

Activity:	Tissue activity of this recombinase allele
Driver:	Kit (mouse) Summary of all recombinase alleles driven by Kit. Alliance mouse Kit gene page

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Kit Mutation:	179 strains or lines available

Original:	J:278090 He L, et al., Reassessment of c-Kit(+) Cells for Cardiomyocyte Contribution in Adult Heart. Circulation. 2019 Jul 9;140(2):164-166
All:	1 reference(s)