Summary | Mutation origin | Mutation description | Recombinase activity | Find Mice (IMSR) | References

Symbol:	Nrg1em1(cre/ERT2)Bzsh
Name:	neuregulin 1; endonuclease-mediated mutation 1, Bin Zhou
MGI ID:	MGI:6361462
Synonyms:	Nrg1-CreER
Gene:	Nrg1  Location: Chr8:32299493-33381858 bp, - strand  Genetic Position: Chr8, 18.75 cM
Alliance:	Nrg1em1(cre/ERT2)Bzsh page

Strain of Origin:

Not Specified

Allele Type:    Endonuclease-mediated (Inducible, Recombinase) Inducer:    tamoxifen Mutation:    Insertion   Nrg1em1(cre/ERT2)Bzsh expression driven by 1 gene Knock-in expression driven by: Organism Driver Gene Note mouse Nrg1 (MGI:96083)   Mutation details: The mouse line was generated by homologous recombination using the CRISPR/Cas9 technology. A complementary DNA encoding Cre recombinase fused with a mutant form of the ESR hormone-binding domain (CreERT2) followed by a polyadenylation sequence, was inserted into the last coding exon of Nrg1 gene, and a 2A peptide sequence was used to link the Nrg1 coding region and CreERT2 cDNA to allow expression of both Nrg1 and CreERT2. (J:278094)

Activity:	Tissue activity of this recombinase allele
Driver:	Nrg1 (mouse) Summary of all recombinase alleles driven by Nrg1. Alliance mouse Nrg1 gene page

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Nrg1 Mutation:	53 strains or lines available

Original:	J:278094 Pu W, et al., Genetic Targeting of Organ-Specific Blood Vessels. Circ Res. 2018 Jun 22;123(1):86-99
All:	1 reference(s)