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Gene Expression Data
Assay Details
Assay
Reference: J:272028 O'Connell AE, et al., Mammalian Hbs1L deficiency causes congenital anomalies and developmental delay associated with Pelota depletion and 80S monosome accumulation. PLoS Genet. 2019 Feb;15(2):e1007917
Assay type: Western blot
MGI Accession ID: MGI:6361176
Gene symbol: Pelo
Gene name: pelota mRNA surveillance and ribosome rescue factor
Antibody: PELO Antibody
Detection system: Secondary antibody coupled to horseradish peroxidase
Results
 Sample Information Bands Other Sample Information
Lane AgeStructure Size Not Specified Genetic BackgroundMutant Allele(s)Sex
Brain KO P TS28: brain Weak (a) C57BL/6N-Hbs1ltm1a(KOMP)Wtsi/Wtsi Hbs1ltm1a(KOMP)Wtsi/Hbs1ltm1a(KOMP)WtsiNot Specified
Brain WT P TS28: brain Present involves: C57BL/6N Not Specified
Sp. Cord KO P TS28: spinal cord Weak (a) C57BL/6N-Hbs1ltm1a(KOMP)Wtsi/Wtsi Hbs1ltm1a(KOMP)Wtsi/Hbs1ltm1a(KOMP)WtsiNot Specified
Sp. Cord WT P TS28: spinal cord Present involves: C57BL/6N Not Specified
Lung KO P TS28: lung Weak (a) C57BL/6N-Hbs1ltm1a(KOMP)Wtsi/Wtsi Hbs1ltm1a(KOMP)Wtsi/Hbs1ltm1a(KOMP)WtsiNot Specified
Lung WT P TS28: lung Present involves: C57BL/6N Not Specified
Liver KO P TS28: liver Strong (b) C57BL/6N-Hbs1ltm1a(KOMP)Wtsi/Wtsi Hbs1ltm1a(KOMP)Wtsi/Hbs1ltm1a(KOMP)WtsiNot Specified
Liver WT P TS28: liver Strong involves: C57BL/6N Not Specified
Kidney KO P TS28: metanephros Present C57BL/6N-Hbs1ltm1a(KOMP)Wtsi/Wtsi Hbs1ltm1a(KOMP)Wtsi/Hbs1ltm1a(KOMP)WtsiNot Specified
Kidney WT P TS28: metanephros Present involves: C57BL/6N Not Specified
Spleen KO P TS28: spleen Strong (b) C57BL/6N-Hbs1ltm1a(KOMP)Wtsi/Wtsi Hbs1ltm1a(KOMP)Wtsi/Hbs1ltm1a(KOMP)WtsiNot Specified
Spleen WT P TS28: spleen Strong involves: C57BL/6N Not Specified
Tricep KO P TS28: triceps brachii Weak (a) C57BL/6N-Hbs1ltm1a(KOMP)Wtsi/Wtsi Hbs1ltm1a(KOMP)Wtsi/Hbs1ltm1a(KOMP)WtsiNot Specified
Tricep WT P TS28: triceps brachii Present involves: C57BL/6N Not Specified
Gastroc KO P TS28: gastrocnemius muscle Weak (a) C57BL/6N-Hbs1ltm1a(KOMP)Wtsi/Wtsi Hbs1ltm1a(KOMP)Wtsi/Hbs1ltm1a(KOMP)WtsiNot Specified
Gastroc WT P TS28: gastrocnemius muscle Present involves: C57BL/6N Not Specified
Quad KO P TS28: quadriceps femoris muscle Weak (a) C57BL/6N-Hbs1ltm1a(KOMP)Wtsi/Wtsi Hbs1ltm1a(KOMP)Wtsi/Hbs1ltm1a(KOMP)WtsiNot Specified
Quad WT P TS28: quadriceps femoris muscle Present involves: C57BL/6N Not Specified
Notes:
(a) Markedly reduced expression compared with the controls.
(b) Still reduced from controls.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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04/16/2024
MGI 6.23 		The Jackson Laboratory