Summary | Mutation origin | Mutation description | Recombinase activity | Find Mice (IMSR) | References

Symbol:	Adcyap1tm1.1(cre/ERT2)Zjh
Name:	adenylate cyclase activating polypeptide 1; targeted mutation 1.1, Z Josh Huang
MGI ID:	MGI:6360920
Gene:	Adcyap1  Location: Chr17:93506448-93513967 bp, + strand  Genetic Position: Chr17, 60.67 cM
Alliance:	Adcyap1tm1.1(cre/ERT2)Zjh page

Germline Transmission:	Earliest citation of germline transmission: J:323692
Parent Cell Line:	v6.5 (ES Cell)
Strain of Origin:	(C57BL/6 x 129S4/SvJae)F1

Allele Type:    Targeted (Inducible, Recombinase) Inducer:    tamoxifen Mutation:    Insertion   Adcyap1tm1.1(cre/ERT2)Zjh expression driven by 1 gene Knock-in expression driven by: Organism Driver Gene Note mouse Adcyap1 (MGI:105094)   Mutation details: A targeting vector was designed to insert an internal ribosome entry site (IRES) fused to a CreER fusion gene followed by a frt-flanked neo cassette upstream of the stop codon of the adenylate cyclase activating polypeptide 1 (Adcyap1) gene. CreER incorporates cre recombinase fused to a G400V/M543A/L544A triple mutation of the human estrogen receptor ligand binding domain. The neomycin cassette was excised with Flp recombinase. (J:323692)

Activity:	Tissue activity of this recombinase allele
Driver:	Adcyap1 (mouse) Summary of all recombinase alleles driven by Adcyap1. Alliance mouse Adcyap1 gene page

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Adcyap1 Mutation:	22 strains or lines available

Original:	J:323692 Matho KS, et al., Genetic dissection of the glutamatergic neuron system in cerebral cortex. Nature. 2021 Oct;598(7879):182-187
All:	1 reference(s)