Summary | Mutation origin | Mutation description | Recombinase activity | Find Mice (IMSR) | Notes | References

Symbol:	Dbhtm1.1(flpo)Pjen
Name:	dopamine beta hydroxylase; targeted mutation 1.1, Patricia Jensen
MGI ID:	MGI:6358815
Synonyms:	DbhFlpo
Gene:	Dbh  Location: Chr2:27055519-27073216 bp, + strand  Genetic Position: Chr2, 19.29 cM
Alliance:	Dbhtm1.1(flpo)Pjen page

Germline Transmission:	Earliest citation of germline transmission: J:101977
Parent Cell Line:	AB2.2 (ES Cell)
Strain of Origin:	129S7/SvEvBrd-Hprt1b-m2

Allele Type:    Targeted (Recombinase) Mutations:    Insertion, Intragenic deletion   Dbhtm1.1(flpo)Pjen expression driven by 1 gene Knock-in expression driven by: Organism Driver Gene Note mouse Dbh (MGI:94864)   Mutation details: A targeting vector containing a Flpo-poly(A) cassette and a loxP-flanked PGK/Em7-Neo cassette was used to replace 107 bp of exon 1 of the gene. Cre-mediated recombination removed the floxed neo cassette. (J:198264)

Activity:	Tissue activity of this recombinase allele
Driver:	Dbh (mouse) Summary of all recombinase alleles driven by Dbh. Alliance mouse Dbh gene page

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Dbh Mutation:	17 strains or lines available

Original:	J:198264 Robertson SD, et al., Developmental origins of central norepinephrine neuron diversity. Nat Neurosci. 2013 Aug;16(8):1016-23
All:	2 reference(s)