Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Adam3tm1Osb
Name:	ADAM metallopeptidase domain 3; targeted mutation 1, Research Institute for Microbial Diseases, Osaka University
MGI ID:	MGI:6358812
Synonyms:	Adam3tm1a(KOMP)Osb
Gene:	Adam3  Location: Chr8:25167241-25215868 bp, - strand  Genetic Position: Chr8, 13.09 cM, cytoband A2
Alliance:	Adam3tm1Osb page

Germline Transmission:	Earliest citation of germline transmission: J:266476
Parent Cell Line:	EGR-G01 (ES Cell)
Strain of Origin:	(129S2/SvPas x C57BL/6NSlc)F1-Tg(CAG-EGFP,Acr-EGFP)2Osb

Allele Type:    Targeted (Null/knockout, Reporter) Mutations:    Insertion, Intragenic deletion   Mutation details: Using targeting vector DPGS00107_A_C12, an IRES:lacZ trapping cassette and a floxed promoter-driven neomycin cassette replaced exons 12-16. (J:266476)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

1 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Adam3 Mutation:	61 strains or lines available

Original:	J:266476 Fujihara Y, et al., Co-expression of sperm membrane proteins CMTM2A and CMTM2B is essential for ADAM3 localization and male fertility in mice. J Cell Sci. 2018 Oct 8;131(19):jcs221481
All:	3 reference(s)