Slc25a46em2Jvt
Endonuclease-mediated Allele Detail
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| Symbol: |
Slc25a46em2Jvt |
| Name: |
solute carrier family 25, member 46; endonuclease-mediated mutation 2, JL Vilotte |
| MGI ID: |
MGI:6358092 |
| Synonyms: |
Tg18 |
| Gene: |
Slc25a46 Location: Chr18:31713217-31743585 bp, - strand Genetic Position: Chr18, 17.79 cM
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| Alliance: |
Slc25a46em2Jvt page
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| Allele Type: |
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Endonuclease-mediated (Null/knockout) |
| Mutations: |
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Insertion, Intragenic deletion
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Mutation details: TALEN genome editing technology was used to generate a 15 bp insertion / 3 bp deletion, causing replacement of 2 amino acids in the encoded protein from the first transmembrane domain by six modified amino-acids. However, no detectable protein was present in mitochondria derived from mutant mice.
(J:242351)
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| Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
| Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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| Carrying any Slc25a46 Mutation: |
24 strains or lines available
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| Original: |
J:242351 Duchesne A, et al., Bovine and murine models highlight novel roles for SLC25A46 in mitochondrial dynamics and metabolism, with implications for human and animal health. PLoS Genet. 2017 Apr;13(4):e1006597 |
| All: |
1 reference(s) |
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Analysis Tools
