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Tg(Nppa-luc,Nppb-Katshuka)1Vmc
Transgene Detail
Summary
Symbol: Tg(Nppa-luc,Nppb-Katshuka)1Vmc
Name: transgene insertion 1, Vincent M Christoffels
MGI ID: MGI:6356007
Synonyms: AC336-Katushka-Luciferas, BAC336LK
Transgene: Tg(Nppa-luc,Nppb-Katshuka)1Vmc  Location: unknown  
Alliance: Tg(Nppa-luc,Nppb-Katshuka)1Vmc page
Transgene
origin
Strain of Origin:  FVB
Transgene
description
Transgene Type:    Transgenic (Reporter)
Mutation:    Insertion
 
Mutation detailsThe BAC336 clone of a mouse 129 SvJ BAC library was modified to create the transgene construct. This clone contains both the Nppa and Nppb genes. The sequences cccacgccagcATGggc and cggcATGgatc at the translation start sites of Nppa and Nppb were replaced by firefly Luciferase and dimeric bright red fluorescent protein Katushka, respectively. Two mouse lines were generated with randomly integrated multiple copies of the Luciferase-Katushka BAC construct (BAC336LK, lines 1 and 2. (J:229075, J:275070)
Expression
In Mice Carrying this Mutation: 1 RNA-Seq or microarray experiment(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
References
Original:  J:229075 Sergeeva IA, et al., A transgenic mouse model for the simultaneous monitoring of ANF and BNP gene activity during heart development and disease. Cardiovasc Res. 2014 Jan 1;101(1):78-86
All:  8 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/18/2025
MGI 6.24
The Jackson Laboratory