Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Bcas1tm1Himo
Name:	brain enriched myelin associated protein 1; targeted mutation 1, Hisashi Mori
MGI ID:	MGI:6343403
Synonyms:	BCAS1-
Gene:	Bcas1  Location: Chr2:170188911-170269765 bp, - strand  Genetic Position: Chr2, 91.41 cM
Alliance:	Bcas1tm1Himo page

Germline Transmission:	Earliest citation of germline transmission: J:242041
Parent Cell Line:	RENKA (ES Cell)
Strain of Origin:	C57BL/6N

Allele Type:    Targeted (Null/knockout) Mutation:    Insertion   Mutation details: A point mutation 12 bases downstream of adenine of the start codon was introduced to generate an in-frame stop codon. A mouse phosphoglycerate kinase promoter-driven neomycin resistantance gene (pgkneo) and a prokaryotic em7 promoter-driven zeocin-resistant gene (em7zeo) was inserted downstream of the engineered point mutation. Western blot analysis confirmed the absence of protein expression in the cerebral cortex and sciatic nerve of homozygote mutant mice. (J:242041)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

1 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Bcas1 Mutation:	40 strains or lines available

Original:	J:242041 Ishimoto T, et al., Mice lacking BCAS1, a novel myelin-associated protein, display hypomyelination, schizophrenia-like abnormal behaviors, and upregulation of inflammatory genes in the brain. Glia. 2017 May;65(5):727-739
All:	1 reference(s)