Summary | Mutation origin | Mutation description | Recombinase activity | Find Mice (IMSR) | References

Symbol:	P2rx2tm1.1(cre)Ttc
Name:	purinergic receptor P2X, ligand-gated ion channel, 2; targeted mutation 1, Thomas E Taylor-Clark
MGI ID:	MGI:6331316
Gene:	P2rx2  Location: Chr5:110487678-110491078 bp, - strand  Genetic Position: Chr5, 53.49 cM
Alliance:	P2rx2tm1.1(cre)Ttc page

Germline Transmission:	Earliest citation of germline transmission: J:290412
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	C57BL/6

Allele Type:    Targeted (Recombinase) Mutation:    Insertion   P2rx2tm1.1(cre)Ttc expression driven by 1 gene Knock-in expression driven by: Organism Driver Gene Note mouse P2rx2 (MGI:2665170)   Mutation details: The targeting vector using bacterial artificial chromosomes (BACs) clone RP23-333M22 and RP23-354O18 was constructed by inserting a 2A-Cre cassette to replace the TGA stop codon of the P2rx2 gene. The Neo cassette flanked by SDA (self-deletion anchor) sites were removed in the cell. The vector was transfected into the C57BL/6 ES cell to establish mouse line by homologous recombination. (J:290412)

Activity:	Tissue activity of this recombinase allele
Driver:	P2rx2 (mouse) Summary of all recombinase alleles driven by P2rx2. Comparative matrix view of recombinase activities Alliance mouse P2rx2 gene page

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any P2rx2 Mutation:	30 strains or lines available

Original:	J:290412 Kim SH, et al., Development of a mouse reporter strain for the purinergic P2X2 receptor. eNeuro. 2020 Jul 15;:ENEURO.0203-20.2020
All:	2 reference(s)